4.7 Article

Controlled Cascade-Release and High Selective Sterilization by Core-Shell Nanogels for Microenvironment Regulation of Aerobic Vaginitis

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Orchestrated Yolk-Shell Nanohybrids Regulate Macrophage Polarization and Dendritic Cell Maturation for Oncotherapy with Augmented Antitumor Immunity

Xiaoyi Zhao et al.

Summary: This study explores the intrinsic immunomodulatory effects of orchestrated nanoparticles to trigger tumor antigen release and reverse immunosuppression in order to achieve potent antitumor immunity and enhanced cancer therapy. The construction of yolk-shell nanohybrids with tailored properties establishes a novel strategy for multifunctional nanoplatforms for effective cancer therapy with immunomodulation-enhanced antitumor immunity. Potent antitumor effects were found to substantially inhibit the growth of both primary and distant tumors, demonstrating the potential of this approach in cancer treatment.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Spatiotemporally Controllable Distribution of Combination Therapeutics in Solid Tumors by Dually Modified Bacteria

Lu Wang et al.

Summary: The study reports a method of spatiotemporally controllable distribution of combination therapeutics in solid tumors mediated by bacteria, which can reprogram the immune microenvironment of the tumor to optimize antitumor efficacy. Combining the localized heating effect of melanin and the immune activation effect of inhibitors can significantly inhibit tumor growth and prolong survival.

ADVANCED MATERIALS (2022)

Review Public, Environmental & Occupational Health

The pathogenesis of prevalent aerobic bacteria in aerobic vaginitis and adverse pregnancy outcomes: a narrative review

Xiaotong Ma et al.

Summary: Aerobic vaginitis is a common cause of negative pregnancy outcomes. This study reviews the common pathogenic bacteria of aerobic vaginitis during pregnancy and the related adverse pregnancy outcomes. The pathogenic bacteria of aerobic vaginitis can produce different toxins or affect the local immunity, leading to the occurrence of infection. Fresh wet mount microscopy is the preferred diagnostic method for aerobic vaginitis. Clindamycin is a common antibiotic used for aerobic vaginitis in pregnant women. The use of products combining probiotics has achieved excellent treatment success. This study provides a reference for future research and early diagnosis and treatment during pregnancy.

REPRODUCTIVE HEALTH (2022)

Article Nanoscience & Nanotechnology

A transistor-like pH-sensitive nanodetergent for selective cancer therapy

Mingdong Liu et al.

Summary: In this study, a nanodetergent that selectively ruptures cancer cell membranes in tumor acidity conditions has been designed, offering a potential strategy for treating drug-resistant cancers.

NATURE NANOTECHNOLOGY (2022)

Review Microbiology

Towards a deeper understanding of the vaginal microbiota

Michael France et al.

Summary: The vaginal microbiota plays a crucial role in vaginal health, with lactobacilli being dominant but other microbes also present. Lack of lactobacilli is associated with adverse health outcomes. The mechanisms behind these associations are not well understood, and more research on causative relationships is needed.

NATURE MICROBIOLOGY (2022)

Article Materials Science, Multidisciplinary

Hydroxybutyl chitosan/oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds

Di Qin et al.

Summary: In this study, self-healing hydrogels loaded with biological exosome nanoparticles derived from bone mesenchymal stem cells were successfully developed. These hydrogels demonstrated excellent self-healing and antibacterial properties, promoting wound healing and tissue remodeling in stretchable wounds.

APPLIED MATERIALS TODAY (2022)

Review Pharmacology & Pharmacy

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Yunjiang Jiang et al.

Summary: AMPs and SMAMPs have attracted significant enthusiasm in the past thirty years due to their unique membrane-active antimicrobial mechanism and broad-spectrum antimicrobial activity. Despite challenges inherent to current design strategies slowing down the clinical translational development of AMPs and SMAMPs, these challenges have triggered efforts to redesign and repurpose AMPs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Biochemistry & Molecular Biology

Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

Ying Luo et al.

Summary: Antimicrobial peptides (AMPs) are considered a new generation of antibiotics with not only antimicrobial activity but also antibiofilm, immune-regulatory, and other activities. Research on the mechanism of action of AMPs can aid in their modification and development, with many studies focusing on this area. AMPs exhibit a dual mechanism of action and possess antifibroblast and anti-inflammatory properties, making them a promising therapeutic prospect.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Microbiology

Aerobic Vaginitis Induced by Escherichia coli Infection During Pregnancy Can Result in Adverse Pregnancy Outcomes Through the IL-4/JAK-1/STAT-6 Pathway

Chong Fan et al.

Summary: A study found that early embryonic infection with Escherichia coli during pregnancy may lead to decreased maternal and fetal weight, as well as increased placental weight. In addition, the infection also affects the expression of a series of immune-related genes, causing a change in polarization of macrophage types.

FRONTIERS IN MICROBIOLOGY (2021)

Review Chemistry, Multidisciplinary

Chemically and Biologically Engineered Bacteria-Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Zhaoting Li et al.

Summary: Bacteria, with their intrinsic biocompatibility and motility, have been utilized as an emerging delivery system in various biomedical applications, drawing wide interest in the diagnosis and treatment of diseases. The synergy of chemical biotechnology and bacteria has opened up many research opportunities, creating a promising frontier in biomedical applications. Research on bacteria-based delivery systems is focusing on emerging advances in diagnosis and therapy, bringing new possibilities to the field.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Construction of Function-Oriented Core-Shell Nanostructures in Hydrogen-Bonded Organic Frameworks for Near-Infrared-Responsive Bacterial Inhibition

Bai-Tong Liu et al.

Summary: The bottle-around-ship strategy was used to fabricate a core-shell heterostructure of UCNPs and HOFs, achieving intriguing NIR-responsive bacterial inhibition toward Escherichia coli.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Liposomes with Water as a pH-Responsive Functionality for Targeting of Acidic Tumor and Infection Sites

Da-Yuan Wang et al.

Summary: DCPA-H2O liposomes with high protonation capability demonstrated enhanced targeting to solid tumors and intra-abdominal infectious biofilms in murine models. Additionally, therapeutic efficacy of ciprofloxacin-loaded DCPA-H2O liposomes in infected wound-healing model exceeded that of clinically applied ciprofloxacin and other liposomes loaded with ciprofloxacin.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Biophysics

Advances of peptides for antibacterial applications

Yuhan Yan et al.

Summary: Peptide antibacterial products with unique mechanisms have attracted broad interest due to their potential in reducing bacterial drug resistance and biocompatibility. The review covers basic types of antimicrobial peptides, factors to enhance antimicrobial effects, important modes of action, and recent applications such as in wound healing, preservative, and antibacterial coatings. Challenges remain in improving antibacterial peptides, but prospects in the field are promising.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Article Chemistry, Multidisciplinary

Enzyme-Responsive Molecular Assemblies Based on Host-Guest Chemistry

Xiao Xiao et al.

Summary: A versatile supramolecular platform was reported to construct enzyme-responsive nanosystems via host-guest interactions, leading to the formation of various nanostructures capable of actively releasing water-soluble molecules or functional nanoparticles in the presence of alpha-amylase.

LANGMUIR (2021)

Article Multidisciplinary Sciences

Responsive core-shell DNA particles trigger lipid-membrane disruption and bacteria entrapment

Michal Walczak et al.

Summary: This article introduces a class of synthetic DNA-based particles that, upon exposure to an external cue, can aggregate, disrupt lipid membranes, and arrest the motion of bacteria.

NATURE COMMUNICATIONS (2021)

Article Immunology

Composition of Vaginal Microbiota in Pregnant Women With Aerobic Vaginitis

Kwan Young Oh et al.

Summary: This study investigated the vaginal microbiota of pregnant women with aerobic vaginitis (AV), finding lower levels of Lactobacillus crispatus in the AV groups compared to normal flora, while other species were higher. The decrease in L. crispatus relative abundance was common across multiple criteria of the AV scoring system, suggesting a potential influence on AV.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Engineering, Biomedical

Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel

Kai Han et al.

Summary: Modulating the gut microbiome with orally administered gel can induce systemic antitumour immunity and enhance the activity of immune checkpoint inhibitors in murine tumour models. This method shows promise for treating pathologies associated with dysregulated gut microbiome.

NATURE BIOMEDICAL ENGINEERING (2021)

Article Materials Science, Biomaterials

Gelatinase-responsive release of an antibacterial photodynamic peptide against Staphylococcus aureus

Lin Qiu et al.

Summary: A gelatinase-responsive antibacterial photodynamic nanocomposite was designed to selectively kill S. aureus and promote rapid healing of infected wounds, showing significant photodynamic antibacterial activity in a mouse model of staphylococcal skin wound infection.

BIOMATERIALS SCIENCE (2021)

Review Infectious Diseases

The effects of inulin on gut microbial composition: a systematic review of evidence from human studies

Quentin Le Bastard et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

Article Nanoscience & Nanotechnology

Cationic Organic Nanoaggregates as AIE Luminogens for Wash-Free Imaging of Bacteria and Broad-Spectrum Antimicrobial Application

Abhiram Panigrahi et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Review Urology & Nephrology

The microbiome and gynaecological cancer development, prevention and therapy

Pawel Laniewski et al.

NATURE REVIEWS UROLOGY (2020)

Article Medicine, Research & Experimental

Differential Expression of Local Immune Response Genes in the Vagina: Implication for the Diagnosis of Vaginal Infections

O. Budilovskaya et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

Review Multidisciplinary Sciences

Antimicrobial peptides: Application informed by evolution

Brian P. Lazzaro et al.

SCIENCE (2020)

Review Nutrition & Dietetics

Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults

Michele Pier Luca Guarino et al.

NUTRIENTS (2020)

Review Nutrition & Dietetics

Postbiotics-A Step Beyond Pre- and Probiotics

Jakub Zolkiewicz et al.

NUTRIENTS (2020)

Review Materials Science, Biomaterials

Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis

Pengfei Zou et al.

BIOMATERIALS SCIENCE (2020)

Article Biophysics

Mechanical properties of gelatin nanoparticles in dependency of crosslinking time and storage

Agnes-Valencia Weiss et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

Article Biophysics

Strategies for surface modification of gelatin-based nanoparticles

Mohaddeseh Mahmoudi Saber

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

Article Biochemistry & Molecular Biology

Vaginal microbiome transplantation in women with intractable bacterial vaginosis

Ahinoam Lev-Sagie et al.

NATURE MEDICINE (2019)

Article Infectious Diseases

Aerobic vaginitis in late pregnancy and outcomes of pregnancy

Cha Han et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2019)

Article Infectious Diseases

The Pathogenesis Of Streptococcus anginosus In Aerobic Vaginitis

Zhi Tao et al.

INFECTION AND DRUG RESISTANCE (2019)

Review Pharmacology & Pharmacy

Role of inulin as prebiotics on inflammatory bowel disease

Wasim Akram et al.

DRUG DISCOVERIES AND THERAPEUTICS (2019)

Article Nanoscience & Nanotechnology

Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle-Cell Wall Binding Domain Conjugates

Domyoung Kim et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Article Obstetrics & Gynecology

Study on the effects of an oral lactobacilli and lactoferrin complex in women with intermediate vaginal microbiota

Rosario Russo et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2018)

Review Cell Biology

Biological effects of interleukin-6 on Gingival Fibroblasts: Cytokine regulation in periodontitis

Koji Naruishi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Nanoscience & Nanotechnology

Carboxymethyl chitosan nanoparticles loaded with bioactive peptide OH-CATH30 benefit nonscar wound healing

Tongyi Sun et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Review Neurosciences

The vaginal microbiota, host defence and reproductive physiology

Steven B. Smith et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

Review Immunology

Recurrent Urinary Tract Infections in Women: How Promising is the Use of Probiotics?

Varsha Gupta et al.

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY (2017)

Article Agriculture, Multidisciplinary

Self-Assembly and Emulsification Properties of Hydrophobically Modified lnulin

Lingyu Han et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

Review Obstetrics & Gynecology

The role of lactobacilli and probiotics in maintaining vaginal health

Sandra Borges et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2014)

Review Infectious Diseases

Prevalence and treatment of aerobic vaginitis among non-pregnant women: evaluation of the evidence for an underestimated clinical entity

G. S. Tansarli et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2013)

Article Obstetrics & Gynecology

Sialidase activity in aerobic vaginitis is equal to levels during bacterial vaginosis

C. Marconi et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2013)

Article Microbiology

Efficacy of OH-CATH30 and Its Analogs against Drug-Resistant Bacteria In Vitro and in Mouse Models

Sheng-An Li et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Article Microbiology

Gelatinase-Associated Phenotypes and Genotypes Among Clinical Isolates of Enterococcus faecalis in Poland

Janusz Strzelecki et al.

POLISH JOURNAL OF MICROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Structure-function relationship of king cobra cathelicidin

Yong Zhang et al.

PEPTIDES (2010)

Article Obstetrics & Gynecology

Bacterial Populations in the Vaginas of Healthy Adolescent Women

Ted Yamamoto et al.

JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY (2009)

Article Biochemistry & Molecular Biology

Identification and characterization of novel reptile cathelicidins from elapid snakes

Hui Zhao et al.

PEPTIDES (2008)

Article Pharmacology & Pharmacy

Preparation of avidin-labelled gelatin nanoparticles as carriers for biotinylated peptide nucleic acid (PNA)

C Coester et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2000)