Journal
VIRULENCE
Volume 14, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2022.2150449
Keywords
Mycobacterium tuberculosis; tuberculosis; virulence factors; infectious disease; host-pathogen interactions
Categories
Ask authors/readers for more resources
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, posing one of the greatest threats to global health. By utilizing its arsenal of virulence factors, Mtb invades the airway, evades the host immune response, and establishes a niche for survival. Understanding the interplay between Mtb virulence factors and host defenses is crucial for developing effective vaccines and therapeutics.
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious disease with one of the highest morbidity and mortality rates worldwide. Leveraging its highly evolved repertoire of non-protein and protein virulence factors, Mtb invades through the airway, subverts host immunity, establishes its survival niche, and ultimately escapes in the setting of active disease to initiate another round of infection in a naive host. In this review, we will provide a concise synopsis of the infectious life cycle of Mtb and its clinical and epidemiologic significance. We will also take stock of its virulence factors and pathogenic mechanisms that modulate host immunity and facilitate its spread. Developing a greater understanding of the interface between Mtb virulence factors and host defences will enable progress toward improved vaccines and therapeutics to prevent and treat tuberculosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available