Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 594, Issue 18, Pages 5135-5147Publisher
WILEY
DOI: 10.1113/JP270654
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Funding
- Jena Centre for Systems Biology of Aging (JenAge) - German Ministry for Education and Research (Bundesministerium fur Bildung und Forschung) [BMBF 0315581]
- German Research Association (Deutsche Forschungsgemeinschaft, DFG) Research Training Group 1715 Molecular Signatures of Adaptive Stress Responses, Jena, Germany
- Swiss National Science Foundation (Schweizerischer Nationalfonds) [SNF 31003A_156031]
- Novartis Foundation for Medical-Biological Research [14C149]
- European Foundation for the Study of Diabetes (EFSD/Lilly Research Fellowship Programme)
- Swiss National Science Foundation (SNF) [31003A_156031] Funding Source: Swiss National Science Foundation (SNF)
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A popular belief is that reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced during exercise by the mitochondria and other subcellular compartments ubiquitously cause skeletal muscle damage, fatigue and impair recovery. However, the importance of ROS and RNS as signals in the cellular adaptation process to stress is now evident. In an effort to combat the perceived deleterious effects of ROS and RNS it has become common practice for active individuals to ingest supplements with antioxidant properties, but interfering with ROS/RNS signalling in skeletal muscle during acute exercise may blunt favourable adaptation. There is building evidence that antioxidant supplementation can attenuate endurance training-induced and ROS/RNS-mediated enhancements in antioxidant capacity, mitochondrial biogenesis, cellular defence mechanisms and insulin sensitivity. However, this is not a universal finding, potentially indicating that there is redundancy in the mechanisms controlling skeletal muscle adaptation to exercise, meaning that in some circumstances the negative impact of antioxidants on acute exercise response can be overcome by training. Antioxidant supplementation has been more consistently reported to have deleterious effects on the response to overload stress and high-intensity training, suggesting that remodelling of skeletal muscle following resistance and high-intensity exercise is more dependent on ROS/RNS signalling. Importantly there is no convincing evidence to suggest that antioxidant supplementation enhances exercise-training adaptions. Overall, ROS/RNS are likely to exhibit a non-linear (hormetic) pattern on exercise adaptations, where physiological doses are beneficial and high exposure (which would seldom be achieved during normal exercise training) may be detrimental.
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