Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 594, Issue 14, Pages 3911-3954Publisher
WILEY
DOI: 10.1113/JP271870
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Funding
- National Institutes of Health [HL084261, HL125730, HL083947, HL71140, HL78931, NS090407, HL113251, NR015038, NR013625, HL65176, HL114024, HL114676, HL132356]
- Strategic Research Initiative of the Indiana University Health/Indiana University School of Medicine
- National Health and Medical Research Council [1081143, 1036352, 1070386]
- National Health and Medical Research Council of Australia [1081143, 1070386] Funding Source: NHMRC
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The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.
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