Nutritional epigenomic and DNA-damage modulation effect of natural stilbenoids

The aim of the present work is the evaluation of biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. In the present study, resveratrol, pterostilbene and for the first time their dimers (+/-)-trans-delta-viniferin, (+/-)-trans-pterostilbene dehydrodimer were evaluated in Caco-2 and HepG-2 cell lines as potential epigenetic modulators. Stilbenoids were added in a Caco-2 cell culture as a model of the intestinal epithelial barrier and in the HepG-2 as a model of hepatic environment, to verify their dose-dependent toxicity, ability to interact with DNA, and epigenomic action. Resveratrol, pterostilbene, and (+/-)-trans-pterostilbene dehydrodimer were found to have no toxic effects at tested concentration and were effective in reversing arsenic damage in Caco-2 cell lines. (+/-)-trans-delta-viniferin showed epigenomic activity, but further studies are needed to clarify its mode of action.

Automated summary

The aim of this study was to evaluate the biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. Resveratrol, pterostilbene, and (+/-)-trans-pterostilbene dehydrodimer showed no toxic effects and were effective in reversing arsenic damage in Caco-2 cell lines. Further studies are needed to clarify the mode of action of (+/-)-trans-delta-viniferin.