4.7 Article

Combined effects of sepsis and extracorporeal membrane oxygenation on left ventricular performance in a murine model

Journal

SCIENTIFIC REPORTS
Volume 12, Issue 1, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41598-022-26145-7

Keywords

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Funding

  1. Chonnam National University Hospital Biomedical Research Institute [BCRI20018, BCRI22022, BCRI22025]
  2. Chonnam National University [2021-2443, 2022-3856-01]
  3. National Research Foundation [NRF-2021R1I1A3047390, NRF-2019R1D1A3A03103899, NRF-2020R1F1A1073921]

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This study investigated the impact of ECMO on left ventricular hemodynamics in septic shock using a murine model. The results showed that ECMO in septic shock was associated with increased myocardial oxygen consumption.
Extracorporeal membrane oxygenation (ECMO) may be a viable salvage therapy in selected patients with septic shock. As ECMO use increases, we studied left ventricular (LV) performance during sepsis with and without ECMO using a pressure-volume (PV) loop in a murine model and aimed to understand LV hemodynamics in septic shock with ECMO. The rats were divided into Group 1 (ECMO applied to healthy rats), Group 2 (ECMO for septic rats), Group 3 (Controls, n = 20) and Group 4 (Sepsis induction only, n = 20). The cardiac parameters include end-diastolic volume (EDV), end-systolic volume (ESV), end-diastolic pressure (EDP), and end-systolic pressure (ESP), ejection fraction (EF), end-systolic elastance (Ees), diastolic time constant (Tau) index, arterial elastance (Ea), pressure-volume area (PVA), stroke work (SW), and potential energy (PE). We compared the changes of parameters in all groups. A total of 74 rats were included in the analyses. After 2 h on ECMO, Group 2 was associated with significant increases in ESP, EDV, ESV, PVA, PE, and SW. The difference ratio of PE and PVA was significantly higher in Group 2 compared to Group 1 (P < 0.01). In conclusion, myocardial oxygen consumption was higher in septic shock with ECMO than in controls.

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