4.6 Review

TRPA1 channels: molecular sentinels of cellular stress and tissue damage

Related references

Note: Only part of the references are listed.
Article Behavioral Sciences

Naturally Produced Defensive Alkenal Compounds Activate TRPA1

Nathaniel T. Blair et al.

CHEMICAL SENSES (2016)

Article Biochemistry & Molecular Biology

How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy

Monique S. J. Brewster et al.

BIOESSAYS (2015)

Article Cell Biology

Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling

M. Carmen Fernandez-Agueera et al.

CELL METABOLISM (2015)

Article Neurosciences

Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels

Daisuke Kozai et al.

CURRENT NEUROPHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Streptozotocin Stimulates the Ion Channel TRPA1 Directly INVOLVEMENT OF PEROXYNITRITE

David A. Andersson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Correction Multidisciplinary Sciences

Structure of the TRPA1 ion channel suggests regulatory mechanisms (vol 520, pg 511, 2015)

Candice E. Paulsen et al.

NATURE (2015)

Article Neurosciences

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

Mufeng Li et al.

NATURE NEUROSCIENCE (2015)

Review Pharmacology & Pharmacy

TRPA1 as a drug target-promise and challenges

Jun Chen et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2015)

Article Neurosciences

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation

Sebastien Talbot et al.

NEURON (2015)

Article Neurosciences

Hydrogen sulfide determines HNO-induced stimulation of trigeminal afferents

Vanessa Wild et al.

NEUROSCIENCE LETTERS (2015)

Article Multidisciplinary Sciences

Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice

Sonja M. Mueller-Tribbensee et al.

PLOS ONE (2015)

Article Multidisciplinary Sciences

Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2

Ananya R. Guntur et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

Michelle N. Sullivan et al.

SCIENCE SIGNALING (2015)

Review Immunology

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease

Jose Ordovas-Montanes et al.

TRENDS IN IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

Michelle N. Sullivan et al.

SCIENCE SIGNALING (2015)

Article Biochemistry & Molecular Biology

A Molecular Framework for Temperature-Dependent Gating of Ion Channels

Sandipan Chowdhury et al.

Review Biochemistry & Molecular Biology

ROS Function in Redox Signaling and Oxidative Stress

Michael Schieber et al.

CURRENT BIOLOGY (2014)

Article Biochemistry & Molecular Biology

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

Gabriela Trevisan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Article Gastroenterology & Hepatology

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

TinaMarie Lieu et al.

GASTROENTEROLOGY (2014)

Article Dentistry, Oral Surgery & Medicine

TRPA1 and TRPV4 Activation in Human Odontoblasts Stimulates ATP Release

O. Egbuniwe et al.

JOURNAL OF DENTAL RESEARCH (2014)

Article Physiology

UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes

Nicholas W. Bellono et al.

JOURNAL OF GENERAL PHYSIOLOGY (2014)

Article Medicine, Research & Experimental

TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma

Yuka Okada et al.

LABORATORY INVESTIGATION (2014)

Article Multidisciplinary Sciences

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

Lavanya Moparthi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

Camilla Fusi et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Victor Meseguer et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

TRPA1 is essential for the vascular response to environmental cold exposure

Aisah A. Aubdool et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

Differential methylation of the TRPA1 promoter in pain sensitivity

J. T. Bell et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway

Mirjam Eberhardt et al.

NATURE COMMUNICATIONS (2014)

Article Neurosciences

Defining the nociceptor transcriptome

Matthew Thakur et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Article Pharmacology & Pharmacy

Mouse Monoclonal Antibodies to Transient Receptor Potential Ankyrin 1 Act as Antagonists of Multiple Modes of Channel Activation

Ki Jeong Lee et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

Review Cell Biology

TRP Channels and Pain

David Julius

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 29 (2013)

Review Physiology

TRPA1: A Gatekeeper for Inflammation

Diana M. Bautista et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)

Article Immunology

TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis

Min-Hee Oh et al.

JOURNAL OF IMMUNOLOGY (2013)

Article Neurosciences

Modulation of TRP channels by resveratrol and other stilbenoids

Lina Yu et al.

MOLECULAR PAIN (2013)

Article Multidisciplinary Sciences

Bacteria activate sensory neurons that modulate pain and inflammation

Isaac M. Chiu et al.

NATURE (2013)

Article Multidisciplinary Sciences

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

Maofu Liao et al.

NATURE (2013)

Article Neurosciences

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

David P. Roberson et al.

NATURE NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes

Nicholas W. Bellono et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Species differences and molecular determinant of TRPA1 cold sensitivity

Jun Chen et al.

NATURE COMMUNICATIONS (2013)

Article Multidisciplinary Sciences

A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain

Cristina Nativi et al.

SCIENTIFIC REPORTS (2013)

Article Gastroenterology & Hepatology

Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon

Izumi Kaji et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Review Pharmacology & Pharmacy

The functions of TRPA1 and TRPV1: moving away from sensory nerves

E. S. Fernandes et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Review Pharmacology & Pharmacy

TRPA1 channels in the vasculature

Scott Earley

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

Irina Vetter et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

Denisa May et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

Lucie Sura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1) A POSSIBLE MECHANISM OF METABOLIC NEUROPATHIES

Mirjam J. Eberhardt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

TRPA1 Is a Polyunsaturated Fatty Acid Sensor in Mammals

Arianne L. Motter et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation

Richard C. Lennertz et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

David A. Andersson et al.

PLOS ONE (2012)

Article Physiology

TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism

Serena Materazzi et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)

Review Physiology

The transient receptor potential channel TRPA1: from gene to pathophysiology

Bernd Nilius et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)

Review Biochemistry & Molecular Biology

Chemosensory Properties of the Trigeminal System

Felix Viana

ACS CHEMICAL NEUROSCIENCE (2011)

Article Gastroenterology & Hepatology

TRPA1 and Substance P Mediate Colitis in Mice

Matthias A. Engel et al.

GASTROENTEROLOGY (2011)

Editorial Material Neurosciences

Could an Allosteric Gating Model Explain the Role of TRPA1 in Cold Hypersensitivity?

Marcelo Salazar et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Neurosciences

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

Stuart M. Brierley et al.

JOURNAL OF PHYSIOLOGY-LONDON (2011)

Article Biochemistry & Molecular Biology

TRPA1 underlies a sensing mechanism for O2

Nobuaki Takahashi et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Multidisciplinary Sciences

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

Julio F. Cordero-Morales et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

David E. Clapham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol

David A. Andersson et al.

NATURE COMMUNICATIONS (2011)

Review Pharmacology & Pharmacy

TRP channels as sensors and signal integrators of redox status changes

Nobuaki Takahashi et al.

FRONTIERS IN PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Regulation of Nociceptive Transmission at the Periphery Via TRPA1-TRPV1 Interactions

Armen N. Akopian

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)

Letter Dermatology

Exposure to Low Temperature Induces Elevation of Intracellular Calcium in Cultured Human Keratinocytes

Moe Tsutsumi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

Article Neurosciences

TRPA1 Contributes to Cold Hypersensitivity

Donato del Camino et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

TRPA1 Is a Component of the Nociceptive Response to CO2

Yuanyuan Y. Wang et al.

JOURNAL OF NEUROSCIENCE (2010)

Review Biochemistry & Molecular Biology

Interactions between the immune and nervous systems in pain

Ke Ren et al.

NATURE MEDICINE (2010)

Review Biochemistry & Molecular Biology

Cellular and Molecular Mechanisms of Pain

Allan I. Basbaum et al.

Article Cardiac & Cardiovascular Systems

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels

Scott Earley et al.

CIRCULATION RESEARCH (2009)

Review Chemistry, Medicinal

TRPA1 modulators in preclinical development

Felix Viana et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2009)

Editorial Material Physiology

Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation

Kelvin Y. Kwan et al.

JOURNAL OF GENERAL PHYSIOLOGY (2009)

Letter Dermatology

Non-Neuronal Expression of Transient Receptor Potential Type A1 (TRPA1) in Human Skin

Ruzanna Atoyan et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

Article Biochemistry & Molecular Biology

Zinc activates damage-sensing TRPA1 ion channels

Hongzhen Hu et al.

NATURE CHEMICAL BIOLOGY (2009)

Article Neurosciences

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

Manuela Schmidt et al.

NEURON (2009)

Article Multidisciplinary Sciences

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

Takashi Miyamoto et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

Ana I. Caceres et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+

David A. Andersson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Pharmacology & Pharmacy

TRPA1: A potential target for anti-tussive therapy

Thomas E. Taylor-Clark et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2009)

Review Neurosciences

Critical role of nociceptor plasticity in chronic pain

David B. Reichling et al.

TRENDS IN NEUROSCIENCES (2009)

Article Urology & Nephrology

The concept of neurogenic inflammation

Pierangelo Geppetti et al.

BJU INTERNATIONAL (2008)

Article Biochemistry & Molecular Biology

TRPA1 channels Novel targets of 1,4-dihydropyridines

Otto Fajardo et al.

CHANNELS (2008)

Article Biochemistry & Molecular Biology

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

Yuanyuan Y. Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Medicine, Research & Experimental

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice

Fumitaka Fujita et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Neurosciences

Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress

David A. Andersson et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Serena Materazzi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Marcello Trevisani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Neurosciences

Nociceptors-noxious stimulus detectors

Clifford J. Woolf et al.

NEURON (2007)

Article Medicine, Research & Experimental

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

Yi Dai et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Dentistry, Oral Surgery & Medicine

NGF up-regulates TRPA1: Implications for orofacial pain

A. Diogenes et al.

JOURNAL OF DENTAL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Transient receptor potential channel a1 is directly gated by calcium ions

Julia F. Doerner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Neurosciences

Direct activation of the ion channel TRPA1 by Ca2+

Sandra Zurborg et al.

NATURE NEUROSCIENCE (2007)

Article Multidisciplinary Sciences

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

Lindsey J. Macpherson et al.

NATURE (2007)

Article Cell Biology

DAMPs, PAMPs and alarmins: all we need to know about danger

Marco E. Bianchi

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Multidisciplinary Sciences

TRP channel activation by reversible covalent modification

Andrew Hinman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Transgenic mice with a reduced core body temperature have an increased life span

Bruno Conti et al.

SCIENCE (2006)

Review Physiology

Central pathways of pulmonary and lower airway vagal afferents

Leszek Kubin et al.

JOURNAL OF APPLIED PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

DM Bautista et al.

Article Multidisciplinary Sciences

The danger model: A renewed sense of self

P Matzinger

SCIENCE (2002)