4.7 Article

A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

ColabFold: making protein folding accessible to all

Milot Mirdita et al.

Summary: ColabFold combines fast homology search and optimized model utilization to offer accelerated prediction of protein structures and complexes, with a processing speed that is 40-60 times faster. It serves as a free and accessible platform for protein folding, capable of predicting close to 1,000 structures per day.

NATURE METHODS (2022)

Article Cell Biology

The evolution of metazoan shelterin

Logan R. Myler et al.

Summary: This study investigated the evolutionary origins of the shelterin complex, which is comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1. The study revealed that TRF1 emerged in vertebrates through duplication of a TRF2-like ancestor, and provided insights into the biology of shelterin and its evolution from ancestral telomeric DNA-binding proteins.

GENES & DEVELOPMENT (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Article Biochemistry & Molecular Biology

Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems

Sharon E. Groover et al.

BIOCHEMISTRY (2020)

Article Cell Biology

Characterization of t-loop formation by TRF2

Leonid A. Timashev et al.

NUCLEUS (2020)

Article Multidisciplinary Sciences

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Grzegorz Sarek et al.

NATURE (2019)

Article Multidisciplinary Sciences

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

V. Pragathi Masamsetti et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Telomere Loop Dynamics in Chromosome End Protection

David Van Ly et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it

Ivona Necasova et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection

Delphine Benarroch-Popivker et al.

MOLECULAR CELL (2016)

Review Cell Biology

Stop pulling my strings - what telomeres taught us about the DNA damage response

Eros Lazzerini-Denchi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

Cell death during crisis is mediated by mitotic telomere deprotection

Makoto T. Hayashi et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2

Deanna N. Edwards et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

Ylli Doksani et al.

Article Biochemistry & Molecular Biology

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

Anthony J. Cesare et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

A two-step mechanism for TRF2-mediated chromosome-end protection

Keiji Okamoto et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

Jean-Baptiste Vannier et al.

Article Cell Biology

A three-state model of telomere control over human proliferative boundaries

Anthony J. Cesare et al.

CURRENT OPINION IN CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Five dysfunctional telomeres predict onset of senescence in human cells

Zeenia Kaul et al.

EMBO REPORTS (2012)

Article Biochemistry & Molecular Biology

Serine Phosphorylation Suppresses Huntingtin Amyloid Accumulation by Altering Protein Aggregation Properties

Rakesh Mishra et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

Article Biochemical Research Methods

Development of a Chemical Genetic Approach for Human Aurora B Kinase Identifies Novel Substrates of the Chromosomal Passenger Complex

Rutger C. C. Hengeveld et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Review Cell Biology

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

Mar Carmena et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

Makoto T. Hayashi et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Cell Biology

Accelerated in vivo epidermal telomere loss in Werner syndrome

Naoshi Ishikawa et al.

AGING-US (2011)

Article Biochemistry & Molecular Biology

Phosphorylation of Annexin A1 by TRPM7 Kinase: A Switch Regulating the Induction of an α-Helix

Maxim V. Dorovkov et al.

BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Identification of a Coiled Coil in Werner Syndrome Protein That Facilitates Multimerization and Promotes Exonuclease Processivity

J. Jefferson P. Perry et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

Anthony J. Cesare et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The Werner syndrome protein binds replication fork and Holliday junction DNAs as an oligomer

Sarah A. Compton et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

A topological mechanism for TRF2-enhanced strand invasion

Simon Amiard et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

JJP Perry et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA

A Machwe et al.

ONCOGENE (2004)

Article Biochemistry & Molecular Biology

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

DK Orren et al.

BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

PL Opresko et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

P Mohaghegh et al.

NUCLEIC ACIDS RESEARCH (2001)