Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance

Article Biochemistry & Molecular Biology

Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives

Hardeep Singh Tuli et al.

Summary: Plant-derived butein exhibits diverse anticancer effects, including antiangiogenic and antimetastatic activities. It interacts with multiple cellular targets and regulates various intracellular signal transduction pathways.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Cell Biology

Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells

Feng Gao et al.

Summary: In this study, it was found that licochalcone A exhibited anti-tumor efficacy in NSCLC cells by directly targeting EGFR signaling, inducing apoptosis, and decreasing survivin protein levels. By inhibiting EGFR kinase activity and downstream pathways, licochalcone A may serve as a potential therapeutic agent for NSCLC.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Biochemistry & Molecular Biology

BIRC3 and BIRC5: multi-faceted inhibitors in cancer

Raffaele Frazzi

Summary: BIRC3 and BIRC5 are members of the IAPs family, with the former potentially promoting survival in cancer cells while the latter is often considered an anti-apoptotic molecule. Their roles in different types of tumors vary and their potential as therapeutic targets is still under investigation.

CELL AND BIOSCIENCE (2021)

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Article Oncology

A survivin-driven, tumor-activatable minicircle system for prostate cancer theranostics

TianDuo Wang et al.

Summary: The study developed a novel cancer detection and treatment method based on a minicircle system, which has potential clinical applications. By regulating tumor-specific promoters, the system can specifically express transgenes in cancer cells and achieve urine-based cancer detection and gene-directed enzyme prodrug therapy.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Food Science & Technology

Probiotic Saccharomyces cerevisiae var. boulardii supernatant inhibits survivin gene expression and induces apoptosis in human gastric cancer cells

Babak Pakbin et al.

Summary: The study showed that SBS can reduce cell viability, induce apoptosis, and decrease survivin gene expression in gastric cancer cells, indicating its potential anticancer effects. Additionally, SBS was more efficient in inducing apoptosis in EPG cells compared to RDB cells.

FOOD SCIENCE & NUTRITION (2021)

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Review Oncology

The diagnostic value of EBV-DNA and EBV-related antibodies detection for nasopharyngeal carcinoma: a meta-analysis

Weixing Liu et al.

Summary: This study found through a meta-analysis that EBV-DNA, VCA-IgA, EBNA1-IgA, and Rta-IgG detection have high accuracy in early diagnosis of nasopharyngeal carcinoma, with EBV-DNA having the highest diagnostic accuracy. Meanwhile, EA-IgA is suitable for diagnosis but not for screening of NPC.

CANCER CELL INTERNATIONAL (2021)

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Article Cell Biology

Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance

Ming Li et al.

Summary: Research identified Tanshinone IIA as a potential Aurora B kinase inhibitor, which can inhibit malignant phenotypes of oral squamous cell carcinoma and has therapeutic potentials for cancer treatment.

CELL DEATH & DISEASE (2021)

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Review Oncology

The Current Role of Adjuvant Chemotherapy in Locally Advanced Nasopharyngeal Carcinoma

Lin Su et al.

Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

The prognostic significance of survivin expression in patients with HNSCC: a systematic review and meta-analysis

Liu-qing Zhou et al.

Summary: Our comprehensive meta-analysis revealed that survivin expression is significantly correlated with poorer overall survival and disease-free survival/disease-specific survival in HNSCC patients. Additionally, survivin is a potential therapeutic target for HNSCC.

BMC CANCER (2021)

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Review Oncology

The Evolving Epidemiology of Nasopharyngeal Carcinoma

Ellen T. Chang et al.

Summary: This review highlights the recent epidemiologic literature on nasopharyngeal carcinoma, focusing on geographic distribution, the involvement of EBV, and the association with Chinese-style salt-preserved fish. New findings suggest a diminished role of salt-preserved fish, a significant impact of EBV genetic sequence variation, and potential effects of oral health and microbiome. Other studies have revealed associations with infectious mononucleosis and genetic variations in response to EBV infection.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

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Article Cell Biology

Mutant p53 regulates Survivin to foster lung metastasis

Qiaosi Tang et al.

Summary: Esophageal squamous cell carcinoma (ESCC) is a deadly cancer that often metastasizes to the lungs. The study investigated how the p53R175H mutation regulates metastasis in ESCC. Depletion of Trp53R172H in primary tumor cell lines led to reduced invasion and lung metastasis, with the YAP-BIRC5 axis identified as a potential mediator. Survivin, a protein encoded by BIRC5, was found to be upregulated by Trp53R172H and associated with increased metastasis in GI cancers. These findings provide new insights into mutant p53-mediated metastasis.

GENES & DEVELOPMENT (2021)

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Review Oncology

Roles of Inflammasomes in Epstein-Barr Virus-Associated Nasopharyngeal Cancer

Chin King Looi et al.

Summary: Epstein-Barr virus (EBV) infection triggers nasopharyngeal carcinoma (NPC) by activating inflammasomes to induce the production of pro-inflammatory cytokines, but abnormal activation of inflammasomes may lead to chronic inflammation promoting carcinogenesis. Further studies are needed to explore the precise roles and mechanisms of inflammasomes in EBV-associated NPC and the potential of targeting inflammasomes for NPC treatment.

CANCERS (2021)

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Article Oncology

Prognostic Significance of BIRC5/Survivin in Breast Cancer: Results from Three Independent Cohorts

Nina Oparina et al.

Summary: In this study, the activity of BIRC5 in breast cancer patients was explored for clinically relevant information, revealing that high levels of BIRC5 protein or mRNA were associated with poor survival, indicating its potential as a promising cancer survival marker. Different subsets by ER expression and nodal status supported an independent association of high BIRC5 with poor prognosis.

CANCERS (2021)

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Article Pharmacology & Pharmacy

Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors

Willi Jugel et al.

Summary: Efficient nucleic acid carrier systems are crucial for delivering siRNAs for tumor treatment, while targeted nanoparticles can improve tumor cell specificity and increase siRNA levels in tumors. In this study, targeted delivery of Survivin-specific siRNA to tumor cells expressing PSCA led to significant antitumor effects, highlighting the potential of combining different therapeutic approaches for enhanced efficacy.

PHARMACEUTICS (2021)

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Review Oncology

Current approach and novel perspectives in nasopharyngeal carcinoma: the role of targeting proteasome dysregulation as a molecular landmark in nasopharyngeal cancer

Ramon Yarza et al.

Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Chemistry, Medicinal

miR-34a-Mediated Survivin Inhibition Improves the Antitumor Activity of Selinexor in Triple-Negative Breast Cancer

Silvia Martini et al.

Summary: In this study, a combinatorial therapeutic approach using miR-34a ectopic expression to enhance the activity of selinexor in TNBC experimental models showed promising anti-tumor effects. The combination of miR-34a and selinexor reduced the expression of survivin and improved anti-proliferative activity in TNBC cells, suggesting the potential efficacy of a miR-34a-based approach in enhancing selinexor's therapeutic effects in TNBC patients.

PHARMACEUTICALS (2021)

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Review Oncology

Prognostic Value of Survivin in Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis

Wenji Xie et al.

Summary: The meta-analysis shows that survivin expression is associated with poor overall survival, lymph node metastasis, local recurrence, distant metastasis, and a higher clinical stage in nasopharyngeal carcinoma, suggesting its potential as a biomarker for predicting prognosis.

JOURNAL OF CANCER (2021)

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Review Cell Biology