4.6 Article

Numerical simulation and parameter optimization of micromixer device using fuzzy logic technique

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Microfluidic nanomaterials: From synthesis to biomedical applications

Kavitha Illath et al.

Summary: Microfluidic platforms have gained popularity in biomedical research due to their unique features in synthesizing nanomaterials, enabling automated synthesis with high speed and repeatability for specific biomedical applications. The ability of microfluidics to simulate physiological conditions for nanomaterial evaluation and achieve more effective clinical applications is emphasized in this review.

BIOMATERIALS (2022)

Article Engineering, Environmental

Optimum design of micromixer for a non-Newtonian fluid by topology optimization

Xin Dong et al.

Summary: This paper investigates the design of the mixing unit in a T-shape micromixer considering non-Newtonian fluid effects using topology optimization. The optimized structures exhibit superior performance in maximizing mixing quality, especially for non-Newtonian fluids.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Engineering, Chemical

Improvement in mixing efficiency of microfluidic passive mixers functionalized by microstructures created with proton beam lithography

Emad Nady et al.

Summary: This study designed, simulated, and realized various microfluidic passive mixer devices, using microstructures to improve mixing efficiency. By varying the length and areal density of micro walls in a micro wall array, optimal mixing performance was achieved. Fabricated passive micromixers showed excellent mixing efficiency with more densely distributed and longer micro-walls.

CHEMICAL ENGINEERING SCIENCE (2022)

Article Chemistry, Multidisciplinary

Acoustic sharp-edge-based micromixer: a numerical study

Zahra Ghorbani Kharaji et al.

Summary: This study numerically investigates the mixing performance of an acoustic sharp-edge-based micromixer. It is found that adjusting parameters such as driving frequency, displacement amplitude, and sharp edge height, as well as reducing background flow velocity, tip angle, and channel width, can significantly improve the mixing performance and efficiency.

CHEMICAL PAPERS (2022)

Article Biochemical Research Methods

Miniaturized and IoT Enabled Continuous-Flow-Based Microfluidic PCR Device for DNA Amplification

Madhusudan B. Kulkarni et al.

Summary: In this study, a continuous-flow driven microfluidic device for polymerase chain reaction (PCR) was designed and fabricated using the CO2 laser ablation method. The device, with low-cost, battery-powered, automated, integrated, and IoT-enabled features, achieved accurate temperature control for PCR reactions in two thermal zones. The device demonstrated excellent performance in amplification of DNA template and was compared to the conventional PCR instrument.

IEEE TRANSACTIONS ON NANOBIOSCIENCE (2022)

Article Chemistry, Medicinal

The Use of a Staggered Herringbone Micromixer for the Preparation of Rigid Liposomal Formulations Allows Efficient Encapsulation of Antigen and Adjuvant

Fernando Lozano Vigario et al.

Summary: Anionic liposomal formulations with intrinsic tolerogenic capacity have potential applications for autoimmune and inflammatory diseases. This study proposes the use of an off the-shelf staggered herringbone micromixer for the preparation of highly rigid anionic liposomes, achieving better loading efficiency of costy tolerogenic adjuvants and encapsulation of a wide variety of peptides.

JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

Article Chemistry, Multidisciplinary

Effect of non-uniform magnetic field on mixing index of a sinusoidal micromixer

Dariush Bahrami et al.

Summary: In this study, a two-dimensional combined active/passive micromixer was designed and evaluated, and the results showed that the magnetic field improved the mixing quality. The micromixer with sinusoidal walls had better performance compared to the one with a straight channel.

KOREAN JOURNAL OF CHEMICAL ENGINEERING (2022)

Article Mechanics

T-shaped micromixers aligned in a row: characterization of the engulfment regime

Simone Camarri

Summary: In this paper, a simple strategy is proposed to connect multiple T-mixers together in order to increase flow rates. By aligning the mixers in a row and feeding them through shared inlet channels, the proposed devices exhibit engulfment flow regime for mixing. Results from numerical simulation and linear stability analysis show that this strategy can lead to compact devices with engulfment, although differences compared to isolated T-mixers may exist based on the spacing between inlet/outlet channels.

ACTA MECHANICA (2022)

Article Nanoscience & Nanotechnology

Optimum design for the Tesla micromixer

Bahador Abolpour et al.

Summary: This study investigates the optimal design of a two-dimensional Tesla-shaped micromixer for high mixing index and low-pressure drop. The genetic algorithm is used to obtain the optimum structural design, and image processing is used to identify the micromixer edges and generate a mesh configuration. The governing equations of laminar fluid flow and concentration are discretized and solved using the finite volume method. The best design is achieved by rotating the central obstacles of the Tesla micromixer, resulting in a lower mixing cost and better performance than the original design.

MICROFLUIDICS AND NANOFLUIDICS (2022)

Article Engineering, Mechanical

Mixing characteristics and pressure drop analysis in a spiral micromixer

Ekta Tripathi et al.

Summary: In this work, numerical computations were used to analyze the mixing characteristics and pressure drop in a spiral micromixer. The study found that the designed micromixer provides better mixing for different Reynolds numbers, while the mixing index remains almost constant with the variation of the depth and width of the mixer.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART E-JOURNAL OF PROCESS MECHANICAL ENGINEERING (2022)

Article Engineering, Electrical & Electronic

Enhanced acoustofluidic mixing in a semicircular microchannel using plate mode coupling in a surface acoustic wave device

Jin-Chen Hsu et al.

Summary: This study presents enhanced acoustic mixing inside a semicircular microfluidic channel using acoustic streaming induced by acoustic plate modes (APMs). By exciting APMs on a 500-μm-thick polished lithium-niobate (LiNbO3) substrate, stronger acoustic streaming flow and stirring effects were observed, leading to rapid and enhanced mixing processes. Finite element simulation and experimental validation were performed to investigate the acoustic process and mixing behaviors. The ability of the device to enhance micromixing using APM frequencies was demonstrated, suggesting the potential for integrated design with surface acoustic waves (SAWs) in a single system. The results also highlight the innovative application of conventional SAW acoustofluidic devices to extended frequency regimes via APMs without altering the substrate thickness and interdigitated transducer (IDT) pitch.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

Article Nanoscience & Nanotechnology

Numerical study of the passive micromixer with the novel blocks

Zhongli Wu et al.

Summary: This paper investigates the effects of different block structures on the mixing performance and pressure drop of passive micromixers. The numerical simulation results show that the micromixer with equilateral triangle blocks achieves high mixing efficiency by breaking the laminar flow state.

AIP ADVANCES (2022)

Article Engineering, Electrical & Electronic

A novel design for split-and-recombine micromixer with double-layer Y-shaped mixing units

Guojun Liu et al.

Summary: A novel Y-shaped split-and-recombine (SAR) micromixer is proposed, which demonstrates better mixing performance and smaller pressure loss due to its three-dimensional structure, splitting recombination, and chaotic convection mechanism. Simulation and experimental results show that the channel aspect ratio has a significant impact on the mixing performance and pressure loss of the micromixer. The micromixer has broad application prospects in chemical synthesis, biochemical analysis, and biomedicine.

SENSORS AND ACTUATORS A-PHYSICAL (2022)

Article Multidisciplinary Sciences

Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer

Manon Ripoll et al.

Summary: Lipid nanoparticles (LNPs) have been widely studied for their potential in RNA and DNA delivery, including as mRNA vectors for COVID vaccines. Microfluidics, particularly the ring micromixer, offers advantages for LNP production, such as high mixing quality, low-stress conditions, and fast preparation. This study focuses on the ring micromixer and identifies three regimes that control the mixing performance. Using cryo-TEM and biochemical analysis, the study also shows the correlation between mixing performance and the characteristics of the LNPs produced. The study emphasizes the importance of flow-rate ratio and proposes a physical criterion for producing LNPs with optimal characteristics.

SCIENTIFIC REPORTS (2022)

Article Chemistry, Analytical

Mixing Enhancement of a Passive Micromixer with Submerged Structures

Makhsuda Juraeva et al.

Summary: This article introduces a passive micromixer that combines two different mixing units by submerging planar structures. The study shows that under appropriate conditions, the depth and structure of the submersion can significantly enhance mixing performance and reduce the required pressure load.

MICROMACHINES (2022)

Article Engineering, Electrical & Electronic

Increment of mixing quality of Newtonian and non-Newtonian fluids using T-shape passive micromixer: numerical simulation

Davoud Abbasinezhad Fallah et al.

Summary: This paper presents the design of a T-shape microchannel to enhance mixing quality, validated through numerical simulations and investigates the influence of the number of mixing unit periods and curvature on mixing effectiveness. The best mixing quality was achieved with 25-period mixing unit.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2021)

Article Engineering, Electrical & Electronic

Numerical and experimental investigation of Y-shaped micromixers with mixing units based on cantor fractal structure for biodiesel applications

Imran Shah et al.

Summary: The paper introduces three novel designs of micromixers for evaluating mixing performance in biodiesel preparation. The YCSMSAR micromixer demonstrates the best mixing efficiency at a Reynolds number of 100, with a mixing index of 99.9%.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2021)

Article Nanoscience & Nanotechnology

Design and Analysis of a Laminar Diffusion-Based Micromixer with Microfluidic Chip

Osman Ulkir et al.

Summary: This study aims to optimize diffusion control between channels in a microfluidic-based micromixer by designing and analyzing the micromixer with COMSOL Multiphysics program. Input and output parameters such as diffusion coefficient and inlet flow rate were defined to achieve optimum velocity, pressure, and concentration. Fuzzy Logic method was also utilized to optimize the microfluidic chip based on the analysis data.

JOURNAL OF NANOMATERIALS (2021)

Article Multidisciplinary Sciences

A millisecond passive micromixer with low flow rate, low sample consumption and easy fabrication

Yuanyuan Liao et al.

Summary: This study presents a novel microfluidic mixer based on the staggered herring bone pattern and split-recombination strategies, which improves mixing efficiency and reduces sample consumption. The optimized geometry allows for controlled flow structure rotation and increased contact surface, leading to enhanced mixing effects. The device, fabricated using soft-lithography, demonstrates good mixing performance under low flow rate and small working volume conditions, making it suitable for studies with precious samples.

SCIENTIFIC REPORTS (2021)

Review Engineering, Chemical

A review on acoustic field-driven micromixers

Zahra Ghorbani Kharaji et al.

Summary: Acoustic field-driven micromixers utilize vibration induced by sound waves to improve mixing performance, with air bubbles acting as an external energy source and inducing friction forces at the interface between the bubble and liquid, leading to circulatory flows.

INTERNATIONAL JOURNAL OF CHEMICAL REACTOR ENGINEERING (2021)

Article Chemistry, Multidisciplinary

A novel three-dimensional electroosmotic micromixer based on the Koch fractal principle

Siyue Xiong et al.

Summary: This study designed a new type of micromixer based on the Koch fractal principle. By generating irregular alternating eddy currents in the microchannel under the action of fractal and electric field, the mixing performance of the micromixer was improved. Through numerical calculations and adjustments to the fractal structure, DC voltage size, electrode spacing, and configuration, a micromixer with excellent mixing effect was obtained, with a mixing efficiency of up to 99% when having three groups of alternately placed electrode pairs and Re = 0.01.

RSC ADVANCES (2021)

Article Engineering, Electrical & Electronic

Interface study of the fluids in passive micromixers by altering the geometry of inlets

S. Rahbarshahlan et al.

Summary: This study investigated the improvement of mixing process in a T-shape micromixer, emphasizing the significance of mixing process in microfluidics system. The results showed that an increase in Reynolds number generally increased the mixing coefficient, but specific conditions could disrupt this trend. Factors influencing mixing quality include location, rotation direction, vortexes, and Reynolds number.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2021)

Article Engineering, Mechanical

Numerical study on the mixing quality of an electroosmotic micromixer under periodic potential

Habib Jalili et al.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE (2020)

Article Engineering, Electrical & Electronic

Influence of geometric parameters on the fluidic and mixing characteristics of T-shaped micromixer

Xuekuan Zhan et al.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2020)

Article Nanoscience & Nanotechnology

Phase-controlled field-effect micromixing using AC electroosmosis

Paresa Modarres et al.

MICROSYSTEMS & NANOENGINEERING (2020)

Article Chemistry, Multidisciplinary

Mixing and jetting analysis using continuous flow microfluidic sample delivery devices

Majid Hejazian et al.

RSC ADVANCES (2020)

Proceedings Paper Engineering, Manufacturing

Design and simulation of passive micromixers with ridges for enhanced efficiency

Vidhya Vijayanandh et al.

INTERNATIONAL CONFERENCE ON ADVANCES IN MATERIALS AND MANUFACTURING APPLICATIONS (ICONAMMA-2018) (2019)

Article Engineering, Electrical & Electronic

Numerical and experimental investigations on the performance of a serpentine microchannel with semicircular obstacles

Sandeep Sitaram Wangikar et al.

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS (2018)

Article Chemistry, Multidisciplinary

A hybrid micromixer with planar mixing units

Sajad Razavi Bazaz et al.

RSC ADVANCES (2018)

Article Engineering, Environmental

A micromixer with two-layer serpentine crossing channels having excellent mixing performance at low Reynolds numbers

Shakhawat Hossain et al.

CHEMICAL ENGINEERING JOURNAL (2017)