Journal
RSC ADVANCES
Volume 13, Issue 5, Pages 3083-3094Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra07250e
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In this study, the electrochemical behavior of 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) was investigated in the presence of p-benzoquinone (p-BQ) using cyclic voltammetry. An E-pH diagram for different structures of AMT at various pH values was proposed. The voltammograms revealed an electron transfer + chemical reaction (EC) mechanism. New 1,3,4-thiadiazole derivatives were synthesized by constant current electrolysis. The biological activity of the products was analyzed using an in silico method.
In this study, first, the electrochemical behavior of 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) was fully investigated in the absence and presence of electrochemically generated p-benzoquinone (p-BQ, which is the oxidized form of hydroquinone), as an electrophile, via cyclic voltammetry (CV) at a glassy carbon electrode (GCE) and in an acetic acid buffer (0.2 M)/ethanol solution mixture. Then, an E-pH diagram was proposed for different structures of AMT at various pH values. The obtained voltammograms also exhibited an electron transfer + chemical reaction (EC) mechanism. Besides the voltammetric exploration, electrosynthesis of new 1,3,4-thiadiazole derivatives was conducted by constant current electrolysis (CCE) as a facile and cost-effective method for the formation of S-S and S-C bonds. Finally, the biological activity of products was also analyzed via an in silico method.
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