Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 66, Issue 5, Pages 359-365Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-016-0434-7
Keywords
TRPV2; Mechanical stimulus; Axon outgrowth; Mechanosensor; Thermosensor
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [15H05934, 21200012, 20399554, 24111507 + 26111702, 26117502, 15H03000]
- Uehara Memorial Foundation
- Takeda Science Foundation, Tokyo, Japan
- Sumitomo Foundation
- Brain Science Foundation
- Narishige Neuroscience Research Foundation
- Salt Science Research Foundation [14C2]
- Ichiro Kanehara Foundation
- Grants-in-Aid for Scientific Research [15H03000, 15H05934, 21200012, 26111702, 26117502] Funding Source: KAKEN
Ask authors/readers for more resources
This review provides a summary of the physiological significance of the TRPV2 ion channel. While TRPV2 was initially characterized as a noxious heat sensor, we found that TRPV2 can also act as a mechanosensor in embryonic neurons or adult myenteric neurons. Here, we summarize the newly characterized functions of TRPV2, including the research progress that has been made toward our understanding of TRPV2 physiology, and discuss other recent data pertaining to TRPV2. It is thought that TRPV2 may be an important drug target based on its broad expression patterns and important physiological roles. The possible associations between diseases and TRPV2 are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available