Journal
ADVANCED MATERIALS
Volume 27, Issue 34, Pages 5034-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201501502
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Funding
- National Basic Research Program of China (973 Program) [2013CB932701]
- Chinese Academy of Sciences
- Beijing Natural Science Foundation [2132053]
- National Science Foundation for Post-doctorate studies [2014M560579]
- National Natural Science Foundation of China [21374026, 21304023, 51303036]
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Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment.
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