Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 66, Issue 3, Pages 213-220Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-015-0410-7
Keywords
Cryptotanshinone; Nitric oxide; Soluble cellular adhesion molecule; TNF-alpha; Monocyte adhesion; Chemokine
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Funding
- Ministry of Education, Malaysia [04/04/10/845FR]
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Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis. Salvia miltiorrhiza (danshen) is a traditional Chinese medicine that has been effectively used to treat cardiovascular disease. Cryptotanshinone (CTS), a major lipophilic compound isolated from S. miltiorrhiza, has been reported to possess cardioprotective effects. However, the anti-atherogenic effects of CTS, particularly on tumor necrosis factor-alpha (TNF-alpha)-induced endothelial cell activation, are still unclear. This study aimed to determine the effect of CTS on TNF-alpha-induced increased endothelial permeability, monocyte adhesion, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), monocyte chemoattractant protein 1 (MCP-1) and impaired nitric oxide production in human umbilical vein endothelial cells (HUVECs), all of which are early events occurring in atherogenesis. We showed that CTS significantly suppressed TNF-alpha-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. These observations suggest that CTS possesses anti-inflammatory properties and could be a promising treatment for the prevention of cytokine-induced early atherogenesis.
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