The Metabolic Role of Ketogenic Diets in Treating Epilepsy

Epilepsy is a long-term neurological condition that results in recurrent seizures. Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The ketogenic diet (KD) is considered an effective alternative treatment for epileptic patients. The aim of this study was to identify the metabolic role of the KD in epilepsy. Ketone bodies induce chemical messengers and alterations in neuronal metabolic activities to regulate neuroprotective mechanisms towards oxidative damage to decrease seizure rate. Here, we discuss the role of KD on epilepsy and related metabolic disorders, focusing on its mechanism of action, favorable effects, and limitations. We describe the significant role of the KD in managing epilepsy disorders.

Automated summary

This article discusses the role of the ketogenic diet (KD) in the treatment of epilepsy, suggesting that ketone bodies can regulate neuronal metabolic activities, decrease seizure rate, and have significant therapeutic effects on epilepsy and related metabolic disorders.