4.7 Article

The Positive Effect of 6-Gingerol on High-Fat Diet and Streptozotocin-Induced Prediabetic Mice: Potential Pathways and Underlying Mechanisms

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

Bentong ginger oleoresin mitigates liver injury and modulates gut microbiota in mouse with nonalcoholic fatty liver disease induced by high-fat diet

Kunli Wang et al.

Summary: This study aimed to investigate the effects of Bentong ginger oleoresin (BGO) on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. The results showed that BGO treatment reduced obesity induced by a high-fat diet (HFD), decreased serum total cholesterol levels, and improved liver fat accumulation. Furthermore, BGO exhibited anti-inflammatory activity and regulated the gut microbiota in NAFLD mice. These findings suggest that BGO may serve as an effective dietary supplement for the improvement of NAFLD-related metabolic diseases.

JOURNAL OF FOOD SCIENCE (2022)

Article Chemistry, Medicinal

Antioxidant effects of astaxanthin and metformin combined therapy in type 2 diabetes mellitus patients: a randomized double-blind controlled clinical trial

Nikoo Roustaei Rad et al.

Summary: The study demonstrates that AST supplementation in combination with metformin has a synergistic effect in controlling oxidative stress in T2DM patients. This combination therapy improves antioxidant capacity by inducing Nrf2 transcription factor and activating SOD and catalase. Consequently, AST and metformin together may be beneficial in modifying oxidative stress and preventing T2DM complications.

RESEARCH IN PHARMACEUTICAL SCIENCES (2022)

Article Pharmacology & Pharmacy

Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds

Rhea Subba et al.

Summary: There is a strong bidirectional association between depression and Type 2 diabetes mellitus, with oxidative stress and chronic inflammation playing a crucial role in the development of both disorders. Nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of antioxidant responses and its activation can potentially help manage these comorbid conditions.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Article Agriculture, Multidisciplinary

Fu Brick Tea Manages HFD/STZ-Induced Type 2 Diabetes by Regulating the Gut Microbiota and Activating the IRS1/PI3K/Akt Signaling Pathway

Bangran Qi et al.

Summary: The antidiabetic effects of Fu brick tea aqueous extract (FTE) were investigated in type 2 diabetes mellitus (T2DM) mice. FTE treatment alleviated dyslipidemia, insulin resistance, hepatic oxidative stress, and gut dysbiosis caused by T2DM. FTE activated the IRS1/PI3K/Akt pathway, regulated the intestinal metabolites, and improved colonic short-chain fatty acid levels in T2DM mice.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

6,8-(1,3-Diaminoguanidine) luteolin and its Cr complex show hypoglycemic activities and alter intestinal microbiota composition in type 2 diabetes mice

Xiaodong Ge et al.

Summary: By modifying the structure of luteolin, the compounds DAGL and DAGL · Cr were found to improve hyperglycemia in T2DM mice. They achieved this by improving pancreatic islet function, regulating serum and liver biochemical indicators, repairing damaged tissues, and regulating the PI3K/AKT-1 signaling pathway. Moreover, DAGL and DAGL · Cr also regulated the structure of the intestinal microbiota and increased the content of short-chain fatty acids (SCFA) in the feces, alleviating the symptoms of hyperglycemia in T2DM mice.

FOOD & FUNCTION (2022)

Article Plant Sciences

Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway

Pin Gong et al.

Summary: Astragaloside IV (AS-IV) significantly reversed abnormalities in diabetic mice, protected cellular architecture, and regulated intestinal flora. Its anti-diabetic effects are mediated through modulating the AMPK/SIRT1 and PI3K/AKT signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

A bioinformatics and transcriptomics based investigation reveals an inhibitory role of Huanglian-Renshen-Decoction on hepatic glucose production of T2DM mice via PI3K/Akt/FoxO1 signaling pathway

Fan Wu et al.

Summary: The study demonstrated that Huanglian-Renshen-Decoction (HRD) can treat type 2 diabetes mellitus (T2DM) by inhibiting hepatic glucose production through activating the PI3K/Akt/FoxO1 signaling pathway.

PHYTOMEDICINE (2021)

Article Pharmacology & Pharmacy

6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation

Saleh A. Almatroodi et al.

Summary: The study demonstrates that 6-gingerol has a significant role in ameliorating renal injury in STZ-induced diabetic rats by reducing blood glucose, improving lipid profile, and enhancing antioxidant enzyme levels.

PHARMACEUTICS (2021)

Article Biochemistry & Molecular Biology

Synergistic effect of lotus seed resistant starch and short-chain fatty acids on mice fecal microbiota in vitro

Xin Li et al.

Summary: The combination of lotus seed resistant starch (LRS) and short-chain fatty acids (SCFAs) can promote the growth of fecal microbiota, increase the production of SCFAs, and influence the intestinal flora, which is beneficial for health and disease management.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Nutrition & Dietetics

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice

Qingyu Zhao et al.

Summary: Supplementing with adzuki bean significantly reduces obesity, lipid accumulation, and liver damage induced by a high-fat diet, while also improving glucose homeostasis and reversing gut microbiota imbalances. The changes in gut microbiota induced by adzuki bean supplementation may be associated with various metabolic pathways.

NUTRIENTS (2021)

Article Nutrition & Dietetics

Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NF-κB Signaling Pathways Mediated by Gut Microbiota

Xin Ren et al.

Summary: The study confirmed the hypoglycemic effect of foxtail millet supplementation in diabetic rats, which was partially mediated by the increased relative abundance of Lactobacillus, activation of the PI3K/AKT signaling pathway, and inhibition of the NF-kappa B signaling pathway.

NUTRIENTS (2021)

Article Biochemistry & Molecular Biology

Zanthoxylum alkylamides ameliorate protein metabolism in type 2 diabetes mellitus rats by regulating multiple signaling pathways

Xunyu Wei et al.

Summary: ZA can improve protein synthesis, suppress protein degradation, and ameliorate protein metabolism disorder by regulating multiple signaling pathways, thereby alleviating T2DM.

FOOD & FUNCTION (2021)

Article Nutrition & Dietetics

Beneficial effects of ginger on prevention of obesity through modulation of gut microbiota in mice

Jing Wang et al.

EUROPEAN JOURNAL OF NUTRITION (2020)

Article Medicine, General & Internal

Relationships among pancreatic beta cell function, the Nrf2 pathway, and IRS2: a cross-sectional study

Yiying Liu et al.

POSTGRADUATE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Ginger prevents obesity through regulation of energy metabolism and activation of browning in high-fat diet-induced obese mice

Jing Wang et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2019)

Review Food Science & Technology

Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

Qian-Qian Mao et al.

FOODS (2019)

Review Medical Laboratory Technology

Polyphenols targeting diabetes via the AMP-activated protein kinase pathway; future approach to drug discovery

Saeideh Momtaz et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2019)

Article Agriculture, Multidisciplinary

6-Gingerol, a Functional Polyphenol of Ginger, Promotes Browning through an AMPK-Dependent Pathway in 3T3-L1 Adipocytes

Jing Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Endocrinology & Metabolism

Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome

Zubin Punthakee et al.

CANADIAN JOURNAL OF DIABETES (2018)

Article Endocrinology & Metabolism

Aberrant intestinal microbiota in individuals with prediabetes

Kristine H. Allin et al.

DIABETOLOGIA (2018)

Review Food Science & Technology

Whole cereal grains and potential health effects: Involvement of the gut microbiota

Lingxiao Gong et al.

FOOD RESEARCH INTERNATIONAL (2018)

Article Biochemistry & Molecular Biology

Pumpkin polysaccharide modifies the gut microbiota during alleviation of type 2 diabetes in rats

Guimei Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Endocrinology & Metabolism

Altered Gut Microbiota in Type 2 Diabetes: Just a Coincidence?

Antonio Sircana et al.

CURRENT DIABETES REPORTS (2018)

Review Biochemistry & Molecular Biology

The PI3K/AKT pathway in obesity and type 2 diabetes

Xingjun Huang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Review Endocrinology & Metabolism

Effects of medicinal food plants on impaired glucose tolerance: A systematic review of randomized controlled trials

A. Demmers et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2017)

Review Multidisciplinary Sciences

Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review

Jing Wang et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2017)

Review Endocrinology & Metabolism

Prediabetes diagnosis and treatment: A review

Nidhi Bansal

WORLD JOURNAL OF DIABETES (2015)

Review Biochemistry & Molecular Biology

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

Simon M. Schultze et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2012)

Article Medicine, General & Internal

Prediabetes: a high-risk state for diabetes development

Adam G. Tabak et al.

LANCET (2012)

Article Biotechnology & Applied Microbiology

Metagenomic biomarker discovery and explanation

Nicola Segata et al.

GENOME BIOLOGY (2011)

Review Cardiac & Cardiovascular Systems

Oxidative Stress and Diabetic Complications

Ferdinando Giacco et al.

CIRCULATION RESEARCH (2010)

Review Medicine, General & Internal

Pathogenesis of type 2 diabetes mellitus

RA DeFronzo

MEDICAL CLINICS OF NORTH AMERICA (2004)

Review Multidisciplinary Sciences

Insulin signalling and the regulation of glucose and lipid metabolism

AR Saltiel et al.

NATURE (2001)