4.7 Article

Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study

Susanne Jaeger et al.

Summary: The study using Mendelian randomization method found an inverse association between higher copper levels and cardiometabolic endpoints risk (such as CAD), suggesting that genetically predicted higher copper levels may play a protective role in the development of CAD and systolic blood pressure.

HUMAN MOLECULAR GENETICS (2022)

Review Medicine, General & Internal

Endometrial cancer

Emma J. Crosbie et al.

Summary: Endometrial cancer is the most common gynaecological cancer in high income countries, with a global rise in incidence. Obesity is the major underlying cause, posing challenges for diagnosis and treatment. Early presentation with postmenopausal bleeding ensures cure, but advanced cases have poor prognosis. Minimally invasive surgical staging and targeted chemotherapeutic strategies are important advances.

LANCET (2022)

Article Medicine, General & Internal

Plasma Circulating Vitamin C Levels and Risk of Endometrial Cancer: A Bi-Directional Mendelian Randomization Analysis

Haoxin Peng et al.

Summary: This study demonstrates a causal relationship between higher circulating vitamin C levels and an increased risk of endometrial cancer, independent of confounders and mediators.

FRONTIERS IN MEDICINE (2022)

Article Biochemistry & Molecular Biology

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

S. Fleur W. Meddens et al.

Summary: The study identified genetic correlations between relative protein intake and obesity, type 2 diabetes, and heart disease; negative genetic correlations between relative carbohydrate and sugar intake and waist circumference, waist-hip ratio, and neighborhood deprivation; and positive genetic correlations between these and physical activity. Fat intake showed no consistent genetic correlations with poor health, but was negatively correlated with educational attainment. No evidence of negative health consequences was found associated with relative carbohydrate, sugar, or fat intake, while relative protein intake was suggested to play a role in metabolic dysfunction.

MOLECULAR PSYCHIATRY (2021)

Article Endocrinology & Metabolism

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

Ju-Sheng Zheng et al.

Summary: Higher plasma vitamin C levels are associated with lower type 2 diabetes risk in European populations, but genetically predicted plasma vitamin C levels do not show a strong association with type 2 diabetes, indicating a discordance between biochemically measured and genetically predicted levels.

DIABETES CARE (2021)

Article Multidisciplinary Sciences

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Jue-Sheng Ong et al.

Summary: A study using a larger set of variants associated with 25(OH)D re-evaluated the relationship between 25(OH)D and cancer, finding no relationship for most cancers except for ovarian cancer and basal cell carcinoma. After adjusting for pigmentation related variables, the association with basal cell carcinoma was attenuated.

NATURE COMMUNICATIONS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Nutrition & Dietetics

Causal relationship between dietary macronutrient composition and anthropometric measures: A bidirectional two-sample Mendelian randomization analysis

Dennis Freuer et al.

Summary: Using a two-sample bidirectional Mendelian randomization approach in European populations, it was found that a low relative proportion of carbohydrates and a high proportion of fat in the diet are causally related to higher BMI and WC. Genetically predicted carbohydrate intake was negatively associated with BMI and WC, while fat intake was positively associated with both anthropometric measures.

CLINICAL NUTRITION (2021)

Article Biology

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Steven Bell et al.

Summary: The meta-analysis of three genome-wide association studies revealed 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. These variants are associated with iron deficiency anemia and iron overload, highlighting their significant role in regulating iron homeostasis.

COMMUNICATIONS BIOLOGY (2021)

Article Medicine, General & Internal

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

Veronika W. Skrivankova et al.

Summary: Mendelian randomisation (MR) studies provide insights into causal effects of modifiable exposures on health outcomes, but are often hindered by inadequate reporting. Reporting guidelines like STROBE-MR help authors communicate critical information clearly and transparently, aiding in evaluating the quality of published studies for readers, reviewers, and journal editors.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Genetics & Heredity

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

Pik Fang Kho et al.

Summary: This study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer, and it reveals shared genetic architecture among endometrial cancer, PCOS, and uterine fibroids. Additionally, a novel genome-wide risk locus for endometrial cancer is identified through multi-trait GWAS analysis.

HUMAN GENETICS (2021)

Article Nutrition & Dietetics

A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer

Caroline W. Cohen et al.

JOURNAL OF NUTRITION (2018)

Article Multidisciplinary Sciences

Identification of nine new susceptibility loci for endometrial cancer

Tracy A. O'Mara et al.

NATURE COMMUNICATIONS (2018)

Article Genetics & Heredity

Distinguishing genetic correlation from causation across 52 diseases and complex traits

Luke J. O'Connor et al.

NATURE GENETICS (2018)

Article Public, Environmental & Occupational Health

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2017)

Editorial Material Medicine, General & Internal

Mendelian Randomization

Connor A. Emdin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Article Public, Environmental & Occupational Health

Endometrial Cancer Trends by Race and Histology in the USA: Projecting the Number of New Cases from 2015 to 2040

Charles Gaber et al.

JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES (2017)

Article Genetics & Heredity

Five endometrial cancer risk loci identified through genome-wide association analysis

Timothy H. T. Cheng et al.

NATURE GENETICS (2016)

Article Genetics & Heredity

Adjusting for Heritable Covariates Can Bias Effect Estimates in Genome-Wide Association Studies

Hugues Aschard et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2015)

Article Mathematical & Computational Biology

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome

Fabiola M. Del Greco et al.

STATISTICS IN MEDICINE (2015)

Article Biochemistry & Molecular Biology

Genome-wide association study of selenium concentrations

Marilyn C. Cornelis et al.

HUMAN MOLECULAR GENETICS (2015)

Article Public, Environmental & Occupational Health

Dietary Carbohydrate Intake, Glycemic Index, and Glycemic Load and Endometrial Cancer Risk: A Prospective Cohort Study

Helen G. Coleman et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2014)

Article Biochemistry & Molecular Biology

Genome-wide association study identifies loci affecting blood copper, selenium and zinc

David M. Evans et al.

HUMAN MOLECULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Genome-wide association study identifies common variants associated with circulating vitamin E levels

Jacqueline M. Major et al.

HUMAN MOLECULAR GENETICS (2011)

Article Biochemistry & Molecular Biology

Genome-wide association study of circulating retinol levels

Alison M. Mondul et al.

HUMAN MOLECULAR GENETICS (2011)

Article Public, Environmental & Occupational Health

Risk of endometrial cancer in relation to individual nutrients from diet and supplements

Rita K. Biel et al.

PUBLIC HEALTH NUTRITION (2011)

Article Urology & Nephrology

Common Genetic Variants Associate with Serum Phosphorus Concentration

Bryan Kestenbaum et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Oncology

Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis

Elisa V. Bandera et al.

CANCER CAUSES & CONTROL (2009)

Article Biochemistry & Molecular Biology

Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway

Aditi Hazra et al.

HUMAN MOLECULAR GENETICS (2009)

Review Mathematical & Computational Biology

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Debbie A. Lawlor et al.

STATISTICS IN MEDICINE (2008)

Article Oncology

Macronutrients, fatty acids and cholesterol intake and endometrial cancer

E. Lucenteforte et al.

ANNALS OF ONCOLOGY (2008)

Article Public, Environmental & Occupational Health

'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?

GD Smith et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2003)