☆ 4.7 Review

Metabolic Homeostasis of Amino Acids and Diabetic Kidney Disease

NUTRIENTS (2023)

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications

Naoyoshi Nagata et al.

Summary: This study investigates the interrelationships among gut microbes, metabolites, and cytokines in COVID-19 and its complications, and validates the results with follow-up data. The results show multiple correlations between COVID-19-related microbes, gut metabolites, and inflammatory cytokine dynamics, especially in severe disease and pneumonia. The study also confirms the concordance of altered metabolites in COVID-19 with their corresponding microbial functional genes.

GASTROENTEROLOGY (2023)

Add to Collection
Editorial Material Endocrinology & Metabolism

Introduction: Standards of Medical Care in Diabetes-2022

DIABETES CARE (2022)

Add to Collection
Letter Respiratory System

Methionine supplementation: potential for improving alveolar macrophage function through reverse cholesterol transport?

Marissa O'Callaghan et al.

EUROPEAN RESPIRATORY JOURNAL (2022)

Add to Collection
Article Medicine, Research & Experimental

Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-KB signaling pathways

Jing Yang et al.

Summary: There is a high prevalence of ventricular arrhythmias related to sudden cardiac death in patients with chronic kidney disease (CKD). The study found that indoxyl sulfate (IS) reduces Ito,f-related proteins and Ito,f density by activating ROS/MAPK and NF-KB signaling pathways, leading to prolonged action potential duration and QT interval, which increases the susceptibility to arrhythmia in CKD patients.

JCI INSIGHT (2022)

Add to Collection
Review Nutrition & Dietetics

The Origins, Evolution, and Future of Dietary Methionine Restriction

Han Fang et al.

Summary: Dietary methionine restriction (MR) can extend lifespan in rats, improve insulin sensitivity, and modulate the transcription and release of hepatic fibroblast growth factor 21 (FGF21) to produce metabolic effects.

ANNUAL REVIEW OF NUTRITION (2022)

Add to Collection
Review Biochemistry & Molecular Biology

The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology

Aikaterini Dimou et al.

Summary: Branched chain amino acids (BCAAs), including leucine, isoleucine, and valine, play crucial roles in protein synthesis regulation and various physiological and metabolic processes such as glucose homeostasis. However, defective catabolism of BCAAs, due to altered enzymatic activity, has been investigated in nutritional and disease states, contributing to the pathogenesis of conditions like diabetes, heart failure, and cancer. Restoring the dysregulated BCAA catabolism may improve outcomes and prevent serious complications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Review Cell Biology

Molecular mechanisms of dietary restriction promoting health and longevity

Cara L. Green et al.

Summary: Dietary restriction with adequate nutrition is considered the gold standard for delaying ageing and extending healthspan and lifespan in various species, as it impacts key nutrient-sensing signalling pathways to promote healthy longevity.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Add to Collection
Article Food Science & Technology

Role of Microbial Metabolites of Histidine in the Development of Colitis

Jiaqi Wu et al.

Summary: Meat-derived metabolite imidazole propionate (IMP) has been found to have detrimental effects on intestinal health and may contribute to the relapse of colitis by impairing the intestinal barrier and affecting the proliferation of goblet cells via the dysregulation of the miR-146b/Notch1 axis.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Add to Collection
Article Multidisciplinary Sciences

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Abhijeet Pataskar et al.

Summary: Activated T cells secrete interferon-gamma to trigger tryptophan depletion by increasing the activity of IDO1 enzyme. However, in-frame protein synthesis continues across tryptophan codons due to the reassignment of tryptophan-to-phenylalanine codons. These substitutants are highly abundant in multiple cancer types and are associated with increased IDO1 expression, oncogenic signaling, and the tumor-immune microenvironment.

NATURE (2022)

Add to Collection
Review Urology & Nephrology

Glomerular hyperfiltration

Monica Cortinovis et al.

Summary: Glomerular hyperfiltration can be categorized as 'absolute' hyperfiltration and 'relative' hyperfiltration. 'Absolute' hyperfiltration occurs in the context of a normal number of functioning nephrons and can be seen in high protein intake, pregnancy, diabetes, obesity, or polycystic kidney disease. 'Relative' hyperfiltration occurs when the number of functioning nephrons is reduced and can be seen in patients with a congenitally reduced nephron number or acquired reduction in nephron mass due to surgery or kidney disease.

NATURE REVIEWS NEPHROLOGY (2022)

Add to Collection
Article Cell Biology

Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate

Keisuke Nakagawa et al.

Summary: Chronic kidney disease and cardiovascular disease are linked, with indoxyl sulfate suggested as a cause. While the involvement of indoxyl sulfate in vascular dysfunction associated with acute kidney injury is not fully understood, this study found impaired vascular endothelial function in the thoracic aorta even after kidney injury recovery, possibly due to excessive reactive oxygen species production.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Add to Collection
Article Nutrition & Dietetics

Unraveling the Metabolic Hallmarks for the Optimization of Protein Intake in Pre-Dialysis Chronic Kidney Disease Patients

Patricia Gonzalez et al.

Summary: The daily amount and quality of protein in enteral nutrition for CKD patients is a controversial issue due to the balance between maintaining muscular proteostasis and preventing uremia. This review discusses the physiological conditions and proteins involved in protein synthesis, as well as the digestive features of common proteins used in enteral nutrition formulations.

NUTRIENTS (2022)

Add to Collection
Editorial Material Cardiac & Cardiovascular Systems

Expanding the Therapeutic World of Tryptophan Metabolism

Gregory A. Wyant et al.

CIRCULATION (2022)

Add to Collection
Review Urology & Nephrology

The impact of dietary nutrient intake on gut microbiota in the progression and complications of chronic kidney disease

Laetitia Koppe et al.

Summary: Chronic kidney disease is associated with changes in the gut microbiota, and diet plays a crucial role in managing the disease. This review discusses the latest research on the interactions between diet and gut microbiota in the context of uremia, and how this knowledge can be used to develop personalized nutrition strategies to prevent the progression of chronic kidney disease to kidney failure and its complications.

KIDNEY INTERNATIONAL (2022)

Add to Collection
Article Multidisciplinary Sciences

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Froukje Vanweert et al.

Summary: This study used NaPB to lower plasma BCAA levels in patients with T2D and found that it improved peripheral insulin sensitivity, muscle mitochondrial oxidative capacity, and whole-body insulin-stimulated carbohydrate oxidation while reducing plasma BCAA and glucose levels.

NATURE COMMUNICATIONS (2022)

Add to Collection
Article Nutrition & Dietetics

Impaired Amino Acid Metabolism and Its Correlation with Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus

Huanhuan Zhu et al.

Summary: This study aimed to reveal the metabolomic signatures in diabetes development and progression by comparing metabolite changes among healthy individuals, type 2 diabetes mellitus patients, and diabetic kidney disease patients. It was found that impaired amino acid metabolism was the main metabolic signature in diabetes, and specific metabolites were associated with the development of diabetic kidney disease.

NUTRIENTS (2022)

Add to Collection
Article Multidisciplinary Sciences

S-Adenosylmethionine-responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis

Parijat Bandyopadhyay et al.

Summary: Methionine and cysteine metabolisms play crucial roles in the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). This study characterized the first enzyme of the transsulfuration pathway, cystathionine beta-synthase (MtbCbs), in Mtb using biochemistry and cryoelectron microscopy. MtbCbs was found to be a heme-less, pyridoxal-5'-phosphate-containing enzyme that is allosterically activated by S-adenosylmethionine (SAM). SAM stabilized MtbCbs by preventing proteasomal degradation, supporting methionine and redox metabolism in Mtb. Genetic deficiency of MtbCbs reduced Mtb survival under conditions of homocysteine overload. The findings highlight the importance of the MtbCbs-SAM axis in coordinating sulfur metabolism in Mtb.

SCIENCE ADVANCES (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Untargeted Metabolomic Plasma Profiling of Emirati Dialysis Patients with Diabetes versus Non-Diabetic: A Pilot Study

Bayan Hassan Banimfreg et al.

Summary: This study utilizes metabolomics to identify blood biomarkers differentiating diabetic kidney disease (DKD) from non-diabetic kidney disease in the Emirati population. Analysis of blood samples from hemodialysis subjects revealed significant metabolites and metabolic pathways associated with clinically confirmed diabetic status and HbA1c values.

BIOMOLECULES (2022)

Add to Collection
Review Nutrition & Dietetics

The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders

Chuang Du et al.

Summary: This article introduces the importance of branched-chain amino acids in human physiology and their association with various metabolic disorders. It also discusses the relationship between the alteration of the branched-chain amino acid catabolism enzyme BCKDK and related diseases. Additionally, the article highlights the interaction between branched-chain amino acids and the gut microbiota.

FRONTIERS IN NUTRITION (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Gut bacterial nutrient preferences quantified in vivo

Xianfeng Zeng et al.

Summary: This study quantitatively examines the inputs and outputs of the mouse gut microbiome using isotope tracing, revealing systematic differences in nutrient use across different bacteria. Diet can shape the microbiome by promoting the growth of bacteria that preferentially use the ingested nutrients.

CELL (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Ginsenoside Compound K Ameliorates Development of Diabetic Kidney Disease through Inhibiting TLR4 Activation Induced by Microbially Produced Imidazole Propionate

Qian Chen et al.

Summary: This study found that ginsenoside compound K (CK) has renoprotective properties in early intervention of diabetic kidney disease (DKD). CK supplementation can improve urine microalbumin and renal morphological abnormalities and play a role through regulating gut microbiota and reducing the levels of histidine-derived microbial metabolite imidazole propionate (IMP) in the serum.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Review Urology & Nephrology

KDIGO 2022 CLINICAL PRACTICE GUIDELINE FOR DIABETES MANAGEMENT IN CHRONIC KIDNEY DISEASE

Ian H. de Boer et al.

Summary: The Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (CKD) is a focused update of the 2020 guideline, providing treatment recommendations for clinicians treating diabetes and CKD based on systematic reviews of relevant studies.

KIDNEY INTERNATIONAL (2022)

Add to Collection
Article Cell Biology

DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

Christopher J. Yuskaitis et al.

Summary: Acute fasting can reduce seizure susceptibility in a DEPDC5-dependent manner through modulation of mTORC1 signaling and amino acid levels, suggesting a rational therapeutic strategy for epilepsy treatment.

CELL REPORTS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Methionine restriction- Association with redox homeostasis and implications on aging and diseases

Yuyu Zhang et al.

Summary: Methionine restriction (MR) is a dietary intervention that has been shown to improve aging-related health conditions and diseases, and potentially prolong lifespan. MR appears to be associated with a reduction in oxidative stress and may be one of the underlying mechanisms for lifespan extension and beneficial health effects.

REDOX BIOLOGY (2022)

Add to Collection
Article Medicine, Research & Experimental

Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease

Nkiruka Arinze et al.

Summary: Chronic kidney disease (CKD) is an independent risk factor for peripheral artery disease (PAD). The role of uremic solutes retained in CKD patients in PAD is not well understood. This study reveals that tryptophan-derived uremic solutes inhibit beta-catenin, a key regulator of angiogenesis, in several cell types including endothelial cells. These solutes downregulate beta-catenin through the aryl hydrocarbon receptor (AHR). CKD mouse models show reduced beta-catenin and blood vessel density in ischemic limbs, which correlates with increased levels of uremic solutes and AHR activity. In a cohort of PAD patients, higher plasma levels of tryptophan metabolites and increased AHR-inducing activity in endothelial cells are associated with an increased risk of adverse limb events. Targeting the tryptophan metabolite/AHR/beta-catenin axis may provide new therapeutic strategies for PAD in CKD patients.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection
Review Endocrinology & Metabolism

Amino Acid Sensing in Metabolic Homeostasis and Health

Xiaoming Hu et al.

Summary: The body's ability to sense and respond to changes in nutrient levels, particularly amino acids, is crucial for survival. Amino acids play dual roles as building blocks for proteins and peptides, as well as important bioactive molecules involved in signaling pathways and metabolic regulation. Imbalance in amino acid sensing signals may be linked to metabolic disorders, highlighting their potential as therapeutic targets.

ENDOCRINE REVIEWS (2021)

Add to Collection
Article Chemistry, Medicinal

Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota

Qian Chen et al.

Summary: The Shenyan Kangfu tablet (SYKFT) can alleviate DKD by regulating renal inflammatory signaling cascades and intestinal microbiota, and specific gut microbiota was found to play a role in the development of DKD.

JOURNAL OF NATURAL MEDICINES (2021)

Add to Collection
Review Pharmacology & Pharmacy

Therapeutic potential of pro-resolving mediators in diabetic kidney disease

Tanwi Vartak et al.

Summary: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease, mainly characterized by chronic inflammation causing glomerulosclerosis and tubulointerstitial fibrosis. Resolution pharmacology using specialized pro-resolving lipid mediators is being explored as a potential approach to address DKD.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection
Article Cell Biology

Methionine as a double-edged sword in health and disease: Current perspective and future challenges

Umashanker Navik et al.

Summary: Methionine plays a vital role in cellular processes, with both restriction and supplementation showing potential benefits, but dosage is crucial. Restriction can extend lifespan, while excessive intake may lead to adverse effects.

AGEING RESEARCH REVIEWS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus

Shuyun Liu et al.

Summary: Impaired BCAA catabolism is strongly associated with chronic inflammation and tissue damage in T2DM, and this effect is at least partly due to the BCKAs-induced macrophage oxidative stress. Targeting BCAA catabolism is a potential strategy to attenuate T2DM and its complications.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Add to Collection
Article Medicine, General & Internal

Development and Validation of a Modified Full Age Spectrum Creatinine-Based Equation to Estimate Glomerular Filtration Rate A Cross-sectional Analysis of Pooled Data

Hans Pottel et al.

Summary: A new SCr-based equation, combining design features of the FAS and CKD-EPI equations, has been developed and validated to estimate glomerular filtration rate more accurately, especially during the transition from adolescence to adulthood. The equation shows low bias and fewer estimation errors across the full age spectrum.

ANNALS OF INTERNAL MEDICINE (2021)

Add to Collection
Review Endocrinology & Metabolism

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

Phillip J. White et al.

Summary: The association of obesity and insulin resistance with increased levels of branched-chain and aromatic amino acids and decreased glycine levels is well-established. Human metabolomics and genetic studies have further confirmed these observations, with preclinical studies identifying mechanisms involved in amino acid homeostasis disruption and its connection to dysregulated glucose and lipid metabolism, particularly in the development of insulin resistance, type 2 diabetes, and cardiovascular diseases.

MOLECULAR METABOLISM (2021)

Add to Collection
Article Medicine, General & Internal

Metabolomic Profiling of Amino Acids in Human Plasma Distinguishes Diabetic Kidney Disease From Type 2 Diabetes Mellitus

Chunyu Zhou et al.

Summary: The study investigated the metabolomic profiling of amino acids in the plasma of patients with diabetic kidney disease (DKD). Significant alterations in amino acid levels were observed in patients with DKD compared to patients with T2DM and healthy controls. Valine and cysteine were identified as potential contributors to the progression of DKD from T2DM, while histidine was identified as a key mediator that could distinguish patients with DKD from healthy controls.

FRONTIERS IN MEDICINE (2021)

Add to Collection
Article Urology & Nephrology

Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney

Yaniv Makayes et al.

Summary: This study found that under conditions of malnutrition during pregnancy, the mTORC1 signaling and methionine metabolism in NPCs have significant effects on nephrogenesis and kidney health in adulthood.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Add to Collection
Article Cardiac & Cardiovascular Systems

Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging

Gabor Czibik et al.

Summary: The study found that aging myocardium leads to elevated plasma levels of the essential amino acid phenylalanine, contributing to cardiac dysfunction. Inhibition of p21 gene can delay this process. Phenylalanine treatment induces premature cardiac deterioration, but this can be reversed through pharmacological or dietary interventions.

CIRCULATION (2021)

Add to Collection
Article Oncology

Homocysteine induces podocyte apoptosis by regulating miR-1929-5p expression through c-Myc, DNMT1 and EZH2

Lin Xie et al.

Summary: The study investigated the molecular mechanisms of how Hcy promotes podocyte apoptosis, finding that high Hcy levels trigger podocyte apoptosis by regulating DNMT1 and EZH2, which are recruited by c-Myc, with microRNA miR-1929-5p playing a crucial regulatory role in this process, as its downregulation suppresses apoptosis.

MOLECULAR ONCOLOGY (2021)

Add to Collection
Article Cell Biology

Circulating proteins protect against renal decline and progression to end-stage renal disease in patients with diabetes

Zaipul I. Md Dom et al.

Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection
Article Nutrition & Dietetics

Plasma Imidazole Propionate Is Positively Correlated with Blood Pressure in Overweight and Obese Humans

Jamie van Son et al.

Summary: In overweight and obese subjects without T2D, plasma ImP concentrations were positively correlated with diastolic blood pressure but not with insulin-sensitivity.

NUTRIENTS (2021)

Add to Collection
Article Health Care Sciences & Services

Prognostic evaluation model of diabetic nephropathy patients

Xiao Tu et al.

Summary: This study analyzed 471 cases of DN to explore the risk factors affecting prognosis, identifying factors such as the course of diabetes, fundus lesions, BMI, and grade of hypertension. The results showed that BMI and hypertension were independent risk factors for DKD survival, and participants in the low risk group had significantly better survival rates. The line map accurately predicted the survival rate of DN patients with an AUC of 0.742.

ANNALS OF PALLIATIVE MEDICINE (2021)

Add to Collection
Letter Oncology

Integrated biomarker profiling of the metabolome associated with impaired fasting glucose and type 2 diabetes mellitus in large-scale Chinese patients

Jianglan Long et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Add to Collection
Editorial Material Urology & Nephrology

Targeting the Gut for Early Diagnosis, Prevention, and Cure of Diabetic Kidney Disease: Is the Phenyl Sulfate Story Another Step Forward?

Enrico Fiaccadori et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

Add to Collection
Article Endocrinology & Metabolism

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

Huishou Zhao et al.

DIABETES (2020)

Add to Collection
Review Nutrition & Dietetics

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

Milan Holecek

NUTRIENTS (2020)

Add to Collection
Review Biochemistry & Molecular Biology

From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism

Ara Koh et al.

MOLECULAR CELL (2020)

Add to Collection
Article Chemistry, Applied

Dietary Luffa cylindrica (L.) Roem promotes branched-chain amino acid catabolism in the circulation system via gut microbiota in diet-induced obese mice

Lu Zhang et al.

FOOD CHEMISTRY (2020)

Add to Collection
Article Cell Biology

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Ara Koh et al.

CELL METABOLISM (2020)

Add to Collection
Article Multidisciplinary Sciences

Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span

Ke Zou et al.

SCIENCE ADVANCES (2020)

Add to Collection
Article Gastroenterology & Hepatology

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes

Cristina Menni et al.

GUT MICROBES (2020)

Add to Collection
Review Cell Biology

The Gut Microbiota at the Service of Immunometabolism

Chloe Michaudel et al.

CELL METABOLISM (2020)

Add to Collection
Article Cell Biology

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

Aviram Kogot-Levin et al.

CELL REPORTS (2020)

Add to Collection
Article Multidisciplinary Sciences

Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function

Lior Lobel et al.

SCIENCE (2020)

Add to Collection
Article Endocrinology & Metabolism

Plasma phenylalanine and tyrosine and their interactions with diabetic nephropathy for risk of diabetic retinopathy in type 2 diabetes

Hui-Huan Luo et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

Add to Collection
Article Nutrition & Dietetics

Use of plasma-free amino acids as biomarkers for detecting and predicting disease risk

Kenji Nagao et al.

NUTRITION REVIEWS (2020)

Add to Collection
Article Multidisciplinary Sciences

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Review Endocrinology & Metabolism

Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis

Jianglan Long et al.

BMC ENDOCRINE DISORDERS (2020)

Add to Collection
Article Endocrinology & Metabolism

Plasma tyrosine and its interaction with low high-density lipoprotein cholesterol and the risk of type 2 diabetes mellitus in Chinese

Jing Li et al.

JOURNAL OF DIABETES INVESTIGATION (2019)

Add to Collection
Review Biotechnology & Applied Microbiology

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Michael Platten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Add to Collection
Article Neurosciences

The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain - implications for longevity

Dusan Mladenovic et al.

REVIEWS IN THE NEUROSCIENCES (2019)

Add to Collection
Editorial Material Multidisciplinary Sciences

Branched-chain amino acids in disease

Phillip J. White et al.

SCIENCE (2019)

Add to Collection
Article Medicine, General & Internal

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

Andre B. P. van Kuilenburg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Add to Collection
Article Cell Biology

Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway

Samantha Milanesi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Add to Collection
Article Multidisciplinary Sciences

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Koichi Kikuchi et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Review Medicine, General & Internal

The path toward using microbial metabolites as therapies

Helene C. Descamps et al.

EBIOMEDICINE (2019)

Add to Collection
Article Physiology

Differential Impact of Dietary Branched Chain and Aromatic Amino Acids on Chronic Kidney Disease Progression in Rats

Samyuktha Muralidharan Pillai et al.

FRONTIERS IN PHYSIOLOGY (2019)

Add to Collection
Review Oncology

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sydney M. Sanderson et al.

NATURE REVIEWS CANCER (2019)

Add to Collection
Review Microbiology

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Allison Agus et al.

CELL HOST & MICROBE (2018)

Add to Collection
Article Cell Biology

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

Qiuying Chen et al.

CELL METABOLISM (2018)

Add to Collection
Article Endocrinology & Metabolism

Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial

Paul Welsh et al.

DIABETOLOGIA (2018)

Add to Collection
Review Food Science & Technology

Metabolic Regulation of Methionine Restriction in Diabetes

Jie Yin et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Russell A. Miller et al.

NATURE MEDICINE (2018)

Add to Collection
Article Cell Biology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

Jane M. Natividad et al.

CELL METABOLISM (2018)

Add to Collection
Editorial Material Multidisciplinary Sciences

Histidine degradation boosts cancer therapy

Christian Frezza

NATURE (2018)

Add to Collection
Review Multidisciplinary Sciences

Microbial tryptophan catabolites in health and disease

Henrik M. Roager et al.

NATURE COMMUNICATIONS (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

Ara Koh et al.

CELL (2018)

Add to Collection
Article Medicine, General & Internal

Plasma Branched-Chain Amino Acids and Risk of Incident Type 2 Diabetes: Results from the PREVEND Prospective Cohort Study

Jose L. Flores-Guerrero et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Add to Collection
Review Chemistry, Medicinal

Protective Role of Histidine Supplementation Against Oxidative Stress Damage in the Management of Anemia of Chronic Kidney Disease

Mayra Vera-Aviles et al.

PHARMACEUTICALS (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute Kidney Injury

Yanjun Long et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Add to Collection
Review Urology & Nephrology

Diagnosis and Management of Type 2 Diabetic Kidney Disease

Simit M. Doshi et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Add to Collection
Review Biochemistry & Molecular Biology

Dietary Protein, Metabolism, and Aging

George A. Soultoukis et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway

Kate Campbell et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Add to Collection
Article Multidisciplinary Sciences

Human gut microbes impact host serum metabolome and insulin sensitivity

Helle Krogh Pedersen et al.

NATURE (2016)

Add to Collection
Article Urology & Nephrology

Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-1, and collagen-1

Smeeta Sadar et al.

RENAL FAILURE (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Branched-chain amino acids attenuate early kidney injury in diabetic rats

Na Mi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Add to Collection
Review Endocrinology & Metabolism

Branched-chain amino acids in metabolic signalling and insulin resistance

Christopher J. Lynch et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Add to Collection
Article Multidisciplinary Sciences

Glycemic Effects and Safety of L-Glutamine Supplementation with or without Sitagliptin in Type 2 Diabetes Patients-A Randomized Study

Dorit Samocha-Bonet et al.

PLOS ONE (2014)

Add to Collection
Article Medicine, General & Internal

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

Daren Heyland et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Add to Collection
Article Genetics & Heredity

TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

Annabel A. Ferguson et al.

PLOS GENETICS (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Effects of glutamine supplementation on kidney of diabetic rat

Tatiana Carolina Alba-Loureiro et al.

AMINO ACIDS (2010)

Add to Collection
Article Nutrition & Dietetics

Consequences of low plasma histidine in chronic kidney disease patients: associations with inflammation, oxidative stress, and mortality

Makoto Watanabe et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2008)

Add to Collection
Article Endocrinology & Metabolism

Common variants in glutamine: Fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels

HL Zhang et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)

Add to Collection
Article Biochemical Research Methods

Molecular therapeutic target for type-2 diabetes

KC Chou

JOURNAL OF PROTEOME RESEARCH (2004)

Add to Collection
Article Endocrinology & Metabolism

Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-β1 and fibronectin expression in mesangial cells

C Weigert et al.

DIABETOLOGIA (2003)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.