Related references
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Summary: Since December 2019, SARS-CoV-2 has been rapidly evolving and mutating, leading to various variants with different levels of infectivity and lethality. The most recent variant of concern is Omicron (B.1.1.529), which has raised concerns about its ability to evade pre-existing immunity and overcome antibody-based therapies. Several theories have been proposed to explain the high number of mutations in Omicron. To successfully handle the ongoing pandemic, a multifaceted approach including rapid diagnosis, genome analysis, vaccination, and updated medical facilities is needed.
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Summary: This study analyzed the clinical data of COVID-19 patients admitted to a hospital in Tshwane during the Omicron wave, and found that the severity of the disease was decreased compared to previous waves, with lower death rates and ICU admissions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
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Michela Antonelli et al.
Summary: Despite the high efficacy of COVID-19 vaccines, some individuals still become infected with SARS-CoV-2 post-vaccination. Risk factors for post-vaccination infection include frailty in older adults, living in deprived areas, and obesity. Vaccination is associated with reduced odds of severe symptoms and long-duration illness. The findings suggest the importance of targeting at-risk populations and maintaining infection control measures even in vaccinated individuals.
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Summary: This study investigated the association between vaccination with the BNT162b2 mRNA vaccine and long-term COVID-19 symptoms in individuals infected with SARS-CoV-2. The results showed that individuals who received two doses of the vaccine were less likely to report symptoms such as fatigue, headache, weakness of limbs, and persistent muscle pain compared to those who were unvaccinated. Vaccination with the BNT162b2 vaccine may have a protective effect against longer-term COVID-19 symptoms.
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Om Prakash Mehta et al.
Summary: COVID-19 is a rapidly spreading viral disease transmitted via respiratory droplets, which can affect multiple organ systems. Understanding its diverse clinical presentations can aid in early diagnosis and prevention.
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Summary: Patients with COVID-19 who initially present with symptoms such as dyspnea, hemoptysis, anorexia, diarrhea, or fatigue, especially abdominal pain, should be closely monitored to prevent disease deterioration.
FRONTIERS IN PUBLIC HEALTH
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Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
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Medicine, General & Internal
Hannah R. Whittaker et al.
Summary: The study described the rates for consulting a general practitioner for sequelae after acute covid-19 infection in patients admitted to hospital and those managed in the community. It found differences in sequelae rates between these two groups, with some sequelae decreasing over time while others, such as anxiety and depression, persisted in the community. Rates of some outcomes decreased after vaccination for covid-19.
BMJ-BRITISH MEDICAL JOURNAL
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Destin Groff et al.
Summary: This systematic review found that more than half of COVID-19 survivors experienced PASC 6 months after recovery, with the most common effects being functional mobility impairments, pulmonary abnormalities, and mental health disorders.
Article
Medicine, General & Internal
Hannah E. Davis et al.
Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.
Editorial Material
Public, Environmental & Occupational Health
Mark W. Tenforde et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2020)
