Journal
JOURNAL OF PHYSICS-CONDENSED MATTER
Volume 28, Issue 36, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0953-8984/28/36/363002
Keywords
nucleus; cell migration; mechanics
Categories
Funding
- EPSRC [EP/L026848/1]
- EPSRC [EP/L026848/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L026848/1] Funding Source: researchfish
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Cell migration is important for the function of many eukaryotic cells. Recently the nucleus has been shown to play an important role in cell motility. After giving an overview of cell motility mechanisms we review what is currently known about the mechanical properties of the nucleus and the connections between it and the cytoskeleton. We also discuss connections to the extracellular matrix and mechanotransduction. We identify key physical roles of the nucleus in cell migration.
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