Journal
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
Volume 13, Issue -, Pages 1361-1369Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjnano.13.112
Keywords
antimicrobial agents; bimetallic nanoparticles; gold; silver core-shell; Leishmania; pentamidine; polycyclodextrin
Funding
- Drug Delivery: Veicoli per uninnovazione Sostenibile [PON03PE_00216_1]
- CYCLONET ACRI (Associazione Casse di Risparmio Italiane)
- YOUNG INVESTIGATOR TRAINING PROGRAM
- PON Ricerca e Innovazione
- Azione IV.5 Dottorati e contratti di ricerca su tematiche Innovazione and green
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Advanced nanoscale antimicrobials, combining noble metal nanoparticles with conventional antimicrobial drugs, are considered as the next generation of antimicrobial agents. The demand for rapid, eco-friendly, and relatively inexpensive synthetic approaches for nontoxic metallic nanostructures with unique physicochemical properties is increasing. A straightforward synthetic strategy using polymeric beta-cyclodextrin as the reducing and stabilizing agent has been proposed to produce monodispersed and stable gold-based nanoparticles, either as monometallic structures or core-shell bimetallic architectures with an external silver layer. In this article, the preparation of a supramolecular assembly between these nanoparticles and pentamidine, an antileishmanial drug with a wide range of therapeutic properties, is described. The physicochemical characterization of the supramolecular assembly was investigated by complementary spectroscopic techniques, and the role of PolyCD in the reduction/stabilization of metal nanoparticles was investigated for the first time by NMR spectroscopy.
Advanced nanoscale antimicrobials, originated from the combination of noble metal nanoparticles (NPs) with conventional antimi-crobial drugs, are considered the next generation of antimicrobial agents. Therefore, there is an increasing demand for rapid, eco-friendly, and relatively inexpensive synthetic approaches for the preparation of nontoxic metallic nanostructures endowed with unique physicochemical properties. Recently, we have proposed a straightforward synthetic strategy that exploits the properties of polymeric beta-cyclodextrin (PolyCD) to act as both the reducing and stabilizing agent to produce monodispersed and stable gold-based NPs either as monometallic (nanoG) structures or core-shell bimetallic (nanoGS) architectures with an external silver layer. Here, we describe the preparation of a supramolecular assembly between nanoGS and pentamidine, an antileishmanial drug endowed with a wide range of therapeutic properties (i.e., antimicrobial, anti-inflammatory, and anticancer). The physicochemical characterization of the supramolecular assembly (nanoGSP) in terms of size and colloidal stability was investigated by complemen-tary spectroscopic techniques, such as UV-vis, zeta-potential, and dynamic light scattering (DLS). Furthermore, the role of PolyCD during the reduction/stabilization of metal NPs was investigated for the first time by NMR spectroscopy.
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