Journal
ARABIAN JOURNAL OF CHEMISTRY
Volume 16, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.arabjc.2022.104407
Keywords
Mandelate; Nickel(II)-catalyzed; Esterification; Alcohols
Categories
Funding
- National Natural Science Foundation of China [22061040, 21562039]
- Natural Science Foundation of Xinjiang [2020D01C024]
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This paper reports a nickel-catalyzed esterification reaction for the synthesis of mandelic acid esters with high yields. The reaction is conducted under mild reaction conditions and successfully utilized in the synthesis of medicine cyclandelate.
Mandelates and their derivatives are widely used in organic synthesis, drug discovery, biodegradable polymers and other related fields. Therefore, the effective and simple synthesis of these compounds has attracted much attention. In this paper, a nickel(II)-catalyzed esterification of mandelic acids with different alcohols was realized for the synthesis of mandelic acid esters. This transformation was conducted under mild reaction conditions with yields up to 95%, and was suc-cessfully utilized in the gram-scale synthesis of medicine cyclandelate.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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