Nickel-catalyzed esterification of mandelic acids with alcohols

Mandelates and their derivatives are widely used in organic synthesis, drug discovery, biodegradable polymers and other related fields. Therefore, the effective and simple synthesis of these compounds has attracted much attention. In this paper, a nickel(II)-catalyzed esterification of mandelic acids with different alcohols was realized for the synthesis of mandelic acid esters. This transformation was conducted under mild reaction conditions with yields up to 95%, and was suc-cessfully utilized in the gram-scale synthesis of medicine cyclandelate.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

This paper reports a nickel-catalyzed esterification reaction for the synthesis of mandelic acid esters with high yields. The reaction is conducted under mild reaction conditions and successfully utilized in the synthesis of medicine cyclandelate.