Branched-Selective Hydroacylation of Alkenes via Photoredox Cobalt and N-Heterocyclic Carbene Cooperative Triple Catalysis

A Markovnikov-selective hydroacylation of alkenes has been achieved via the synergistic merger cobalt, photoredox and N-heterocyclic carbene catalysis. The closely incorporated catalytic cycles allow for Co(III) generation by photochemical oxidation instead of chemical oxidants or anodizing process. This mild, operationally simple protocol converts a wide variety of commercially available alkenes and aroyl fluorides into the corresponding ketones in high yield with branched selectivity.

Automated summary

A Markovnikov-selective hydroacylation of alkenes has been achieved by the synergistic merger of cobalt, photoredox, and N-heterocyclic carbene catalysis. The closely interconnected catalytic cycles enable Co(III) generation through photochemical oxidation, eliminating the need for chemical oxidants or anodizing processes. This mild and operationally simple protocol efficiently converts a wide range of commercially available alkenes and aroyl fluorides into ketones with high yield and branched selectivity.