Journal
ACS CATALYSIS
Volume -, Issue -, Pages 1045-1076Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c05247
Keywords
nonheme iron enzymes; natural product biosynthesis; unusual enzyme reactions; enzyme mechanisms; oxygenases
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI) [JP20H00490, JP20KK0173, JP20K22700, JP21K14744, JP21K18246, JP22H05123]
- New Energy and Industrial Technology Development Organization (NEDO) [JPNP20011]
- AMED [JP21ak0101164]
- Japan Science and Technology Agency [JPMJAX2013]
- Japan Foundation for Applied Enzymology
- Kobayashi Foundation
- Koyanagi Foundation
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This review summarizes recent discoveries that have significantly expanded our understanding of unusual nonheme iron enzyme catalysis in natural product biosynthesis.
Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying bioactive organic molecules in all major classes of natural product pathways. While the enzymes have evolved to use a limited repertoire of protein folding and metal binding sites, the oxidation reactions they catalyze are astonishingly diverse, spanning from complex rearrangements to uncommon bond formation and cleavage reactions. This review summarizes recent discoveries that have significantly expanded our understanding of unusual nonheme iron enzyme catalysis in natural product biosynthesis, covering the literature published between 2017 and August 2022.
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