Journal
JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume 49, Issue 8, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0022-3727/49/8/085401
Keywords
giant unilamellar vesicles; lipid peroxidation; membrane permeability; non-thermal plasma jet; OH radicals
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Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2010-0027963, NRF-2014R1A1A1008556]
- Kwangwoon University
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Artificial cell-like model systems can provide information which is hard to obtain with real biological cells. Giant unilamellar vesicles (GUV) containing intra-membrane DNA or OH radical-binding molecules are used to visualize the cytolytic activity of OH radicals. Changes in the GUV membrane are observed by microscopy or flow cytometry as performed for animal cells after non-thermal plasma treatment. The experimental data shows that OH radicals can be detected inside the membrane, although the biological effects are not as significant as for H2O2. This artificial model system can provide a systemic means to elucidate the complex interactions between biological materials and non-thermal plasma.
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