Journal
NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-35601-x
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Funding
- BrainsCAN (Canada First Research Excellence Fund), Accelerator Awards
- Canadian Institutes of Health Research (CIHR) [PJT 162431, PJT 159781]
- Natural Science and Engineering Research Council of Canada [402524-2013 RGPIN, 03592-2021 RGPIN]
- Tanenbaum Open Science Institute (TOSI)
- BrainsCAN Canada First Research Excellence Fund Accelerator Awards
- Rodent Cognition Research and Innovation Core
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The study reveals that the acetylcholine-dopamine signaling in the nucleus accumbens is continuously updated to regulate the neuronal output involved in Pavlovian approach learning.
The ability to learn Pavlovian associations from environmental cues predicting positive outcomes is critical for survival, motivating adaptive behaviours. This cued-motivated behaviour depends on the nucleus accumbens (NAc). NAc output activity mediated by spiny projecting neurons (SPNs) is regulated by dopamine, but also by cholinergic interneurons (CINs), which can release acetylcholine and glutamate via the activity of the vesicular acetylcholine transporter (VAChT) or the vesicular glutamate transporter (VGLUT3), respectively. Here we investigated behavioural and neurochemical changes in mice performing a touchscreen Pavlovian approach task by recording dopamine, acetylcholine, and calcium dynamics from D1- and D2-SPNs using fibre photometry in control, VAChT or VGLUT3 mutant mice to understand how these signals cooperate in the service of approach behaviours toward reward-predicting cues. We reveal that NAc acetylcholine-dopaminergic signalling is continuously updated to regulate striatal output underlying the acquisition of Pavlovian approach learning toward reward-predicting cues.
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