Journal
NETHERLANDS HEART JOURNAL
Volume 31, Issue 7-8, Pages 282-286Publisher
BOHN STAFLEU VAN LOGHUM BV
DOI: 10.1007/s12471-022-01735-2
Keywords
Desmoplakin; Inherited cardiomyopathy; Non-infectious myocarditis; Recurrent cardiac injury; MINOCA
Categories
Ask authors/readers for more resources
We present two female patients with recurrent episodes of myocardial injury, without coronary artery disease. Cardiovascular magnetic resonance imaging and genetic testing showed that they have inherited cardiomyopathy, which may cause myocardial injury similar to acute coronary syndrome or myocarditis.
We present two female patients with recurrent episodes of myocardial injury, consisting of acute chest pain and elevated cardiac markers without coronary artery disease. Cardiovascular magnetic resonance imaging identified extensive late gadolinium enhancement suggestive of an inherited cardiomyopathy. Genetic testing showed heterozygous pathogenic variants in the desmoplakin (DSP) gene, the gene coding for the desmoplakin protein, a structural protein found in the cardiac desmosome. Pathogenic variants in the DSP gene are associated with dilated and arrhythmogenic cardiomyopathy. DSP cardiomyopathies may cause recurring myocardial injury mimicking an acute coronary syndrome or myocarditis. Cardiac magnetic resonance imaging is key in its diagnosis due to its specifying imaging features. Genetic testing is essential for the evaluation and confirmation of the diagnosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available