Salmonella enterica Serovar Typhi on an Island: No H58, No Multidrug Resistance, but for How Long?

Little genomic data is available for typhoid fever from island nations, though the disease has a moderately high burden there. Sikorski et al. (M. J. Sikorski, T. H. Hazen, S. N. Desai, S. Nimarota-Brown, et al., mBio 13:e01920-22, 2022, ) studied 306 Salmonella enterica serovar Typhi genomes from the Samoan Islands collected during 1983 to 2020 and reported dominance of a rare genotype, 2.5.4, and no H58 (genotype 4.3.1). They found pansusceptibility of all isolates to three first lines of antimicrobial agents (ampicillin, chloramphenicol, and cotrimoxazole). This commentary evaluates the importance of these findings for the Samoan Islands and how they can help the global typhoid community. The microbial community in the environment and human gut could have played a role in the lack of antimicrobial resistance (AMR). However, drug-resistant strains may arrive soon at the island, as their international spread is common. Further investigation would help the global typhoid community to better understand the evolution of an isolated pathogen community and the effect of vaccination there.

Automated summary

Little genomic data is available for typhoid fever from island nations. Sikorski et al. studied 306 Typhi genomes from the Samoan Islands and found a dominance of a rare genotype and no drug-resistant strains. It suggests that the lack of antimicrobial resistance may be influenced by the microbial community in the environment and human gut. Further investigation is needed to understand the pathogen evolution and vaccination impact.