Related references
Note: Only part of the references are listed.Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease
Kate L. Jordan et al.
BIOMEDICINES (2022)
Structures of α-synuclein filaments from human brains with Lewy pathology
Yang Yang et al.
NATURE (2022)
α-synuclein aggregation inhibitory activity of the bromotyrosine derivatives aerothionin and aerophobin-2 from the subtropical marine sponge Aplysinella sp
Dale W. Prebble et al.
RESULTS IN CHEMISTRY (2022)
Alpha-Synuclein Aggregates Associated with Mitochondria in Tunnelling Nanotubes
Dario Valdinocci et al.
NEUROTOXICITY RESEARCH (2021)
Membrane Interactions of α-Synuclein Probed by Neutrons and Photons
Upneet Kaur et al.
ACCOUNTS OF CHEMICAL RESEARCH (2021)
Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders
Tuancheng Feng et al.
ACTA NEUROPATHOLOGICA (2021)
Sycosterol A, an α-Synuclein Inhibitory Sterol from the Australian Ascidian Sycozoa cerebriformis
Dale W. Prebble et al.
JOURNAL OF NATURAL PRODUCTS (2021)
α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes
Aysegul Dilsizoglu Senol et al.
PLOS BIOLOGY (2021)
The Genetics of Parkinson's Disease and Implications for Clinical Practice
Jacob Oliver Day et al.
GENES (2021)
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)
Philip Wing-Lok Ho et al.
AUTOPHAGY (2020)
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
Ming-ming Xu et al.
ACTA PHARMACOLOGICA SINICA (2020)
ATP13A2 deficiency disrupts lysosomal polyamine export
Sarah van Veen et al.
NATURE (2020)
Protein Quality Control Pathways at the Crossroad of Synucleinopathies
Eduardo P. De Mattos et al.
JOURNAL OF PARKINSONS DISEASE (2020)
Microglia clear neuron-released a-synuclein via selective autophagy and prevent neurodegeneration
Insup Choi et al.
NATURE COMMUNICATIONS (2020)
The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding
Josquin Courte et al.
SCIENTIFIC REPORTS (2020)
Modeling Parkinson's Disease With the Alpha-Synuclein Protein
Monica Gomez-Benito et al.
FRONTIERS IN PHARMACOLOGY (2020)
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
Amberley D. Stephens et al.
NATURE COMMUNICATIONS (2020)
Anti-prion and α-Synuclein Aggregation Inhibitory Sterols from the Sponge Lamellodysidea cf. chlorea
Laurence K. Jennings et al.
JOURNAL OF NATURAL PRODUCTS (2020)
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts
Mustafa T. Ardah et al.
BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
Anna-Carin Hoffmann et al.
SCIENTIFIC REPORTS (2019)
TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia
Thomas F. Tropea et al.
ANNALS OF NEUROLOGY (2019)
α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons
Qihui Wu et al.
JOURNAL OF NEUROSCIENCE (2019)
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes
Sarah H. Shahmoradian et al.
NATURE NEUROSCIENCE (2019)
Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease
Takuya Uehara et al.
SCIENTIFIC REPORTS (2019)
Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein
Melissa Birol et al.
PLOS BIOLOGY (2019)
Axonal transport: Driving synaptic function
Pedro Guedes-Dias et al.
SCIENCE (2019)
Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network
Simona Gribaudo et al.
STEM CELL REPORTS (2019)
Cell Biology and Pathophysiology of α-Synuclein
Jacqueline Burre et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
The genetics of Parkinson disease
Hao Deng et al.
AGEING RESEARCH REVIEWS (2018)
Enteric nervous system manifestations of neurodegenerative disease
Alcmene Chalazonitis et al.
BRAIN RESEARCH (2018)
Mechanisms of clathrin-mediated endocytosis
Marko Kaksonen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction
He-Jin Lee et al.
CELL DEATH & DISEASE (2018)
Import and Export of Misfoldeda alpha-Synuclein
Lilia Rodriguez et al.
FRONTIERS IN NEUROSCIENCE (2018)
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
Binsen Li et al.
NATURE COMMUNICATIONS (2018)
Membrane binding, internalization, and sorting of alpha-synuclein in the cell
Caterina Masaracchia et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)
The Transcellular Propagation and Intracellular Trafficking of α-Synuclein
George K. Tofaris et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3,5)P2-mediated scaffolding function
S. Demirsoy et al.
HUMAN MOLECULAR GENETICS (2017)
α-synuclein aggregation and its modulation
Dhiman Ghosh et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)
Mesenchymal Stem Cells Stabilize Axonal Transports for Autophagic Clearance of α-Synuclein in Parkinsonian Models
Se Hee Oh et al.
STEM CELLS (2017)
Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein
Marion Delenclos et al.
FRONTIERS IN NEUROSCIENCE (2017)
Evidence for prehistoric origins of the G2019S mutation in the North African Berber population
Rafiqua Ben El Haj et al.
PLOS ONE (2017)
α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients
Birger Victor Dieriks et al.
SCIENTIFIC REPORTS (2017)
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type
Elisabet Ihse et al.
SCIENTIFIC REPORTS (2017)
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins
William P. Flavin et al.
ACTA NEUROPATHOLOGICA (2017)
Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes
Saida Abounit et al.
EMBO JOURNAL (2016)
Rab7 induces clearance of α-synuclein aggregates
Elisabeth Dinter et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
Joseph R. Mazzulli et al.
JOURNAL OF NEUROSCIENCE (2016)
Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges
Lauren R. Kett et al.
MOVEMENT DISORDERS (2016)
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
Marcus D. Tuttle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
Xiaobo Mao et al.
SCIENCE (2016)
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
Carla F. Bento et al.
NATURE COMMUNICATIONS (2016)
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
Marcus D. Tuttle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Structural and functional properties of prefibrillar α-synuclein oligomers
Laura Pieri et al.
SCIENTIFIC REPORTS (2016)
mTOR: a pharmacologic target for autophagy regulation
Young Chul Kim et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
Aoife P. Kiely et al.
MOLECULAR NEURODEGENERATION (2015)
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons
J. C. Koch et al.
CELL DEATH & DISEASE (2015)
Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation
Eun-Jin Bae et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2015)
DNAJC13 mutations in Parkinson disease
Carles Vilarino-Gueell et al.
HUMAN MOLECULAR GENETICS (2014)
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates
Laura A. Volpicelli-Daley et al.
NATURE PROTOCOLS (2014)
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
Petra Pasanen et al.
NEUROBIOLOGY OF AGING (2014)
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein
Eun-Jin Bae et al.
NATURE COMMUNICATIONS (2014)
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function
Owen A. Brady et al.
HUMAN MOLECULAR GENETICS (2013)
The Sac1 Domain of SYNJ1 Identified Mutated in a Family with Early-Onset Progressive Parkinsonism with Generalized Seizures
Catharine E. Krebs et al.
HUMAN MUTATION (2013)
A NOVEL α-SYNUCLEIN MISSENSE MUTATION IN PARKINSON DISEASE
Christos Proukakis et al.
NEUROLOGY (2013)
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson's Disease Risk
David A. MacLeod et al.
NEURON (2013)
DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability
Cigdem Koroglu et al.
PARKINSONISM & RELATED DISORDERS (2013)
Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
David Freeman et al.
PLOS ONE (2013)
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
Brandon B. Holmes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein
He-Jin Lee et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2013)
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease
Yaping Chu et al.
BRAIN (2012)
Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo
Emanuela Colla et al.
JOURNAL OF NEUROSCIENCE (2012)
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
Jacqueline Burre et al.
JOURNAL OF NEUROSCIENCE (2012)
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
Masatoshi Konno et al.
MOLECULAR NEURODEGENERATION (2012)
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M. Danzer et al.
MOLECULAR NEURODEGENERATION (2012)
Genetics of Parkinson's Disease
Christine Klein et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
A deadly spread: cellular mechanisms of α-synuclein transfer
J. A. Steiner et al.
CELL DEATH AND DIFFERENTIATION (2011)
Rab GTPases, Membrane Trafficking and Diseases
Guangpu Li
CURRENT DRUG TARGETS (2011)
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Laura A. Volpicelli-Daley et al.
NEURON (2011)
Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: Conformational heterogeneity of α-synuclein
Agya K. Frimpong et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
Molecular mechanisms of α-synuclein neurodegeneration
Elisa A. Waxman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
Parkinson's disease: from monogenic forms to genetic susceptibility factors
Suzanne Lesage et al.
HUMAN MOLECULAR GENETICS (2009)
Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence
Allan Chris M. Ferreon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
He-Jin Lee et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
alpha-synucleinopathy models and human neuropathology: similarities and differences
Philipp J. Kahle
ACTA NEUROPATHOLOGICA (2008)
Different species of α-synuclein oligomers induce calcium influx and seeding
Karin M. Danzer et al.
JOURNAL OF NEUROSCIENCE (2007)
Impairment of microtubule-dependent trafficking by overexpression of α-synuclein
He-Jin Lee et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Pyrroloquinoline quinone (PQQ) prevents fibril formation of α-synuclein
Masaki Kobayashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Structure and topology of the non-amyloid-β component fragment of human α-synuclein bound to micelles:: Implications for the aggregation process
Marco Bisaglia et al.
PROTEIN SCIENCE (2006)
Epidemiology of Parkinson's disease
Lonneke M. L. de Lau et al.
LANCET NEUROLOGY (2006)
Molecular motors implicated in the axonal transport of tau and α-synuclein
MA Utton et al.
JOURNAL OF CELL SCIENCE (2005)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
Curvature of clathrin-coated pits driven by epsin
MGJ Ford et al.
NATURE (2002)
α-Synuclein is phosphorylated in synucleinopathy lesions
H Fujiwara et al.
NATURE CELL BIOLOGY (2002)
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
KA Conway et al.
SCIENCE (2001)