Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 16, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2022.1016814
Keywords
microRNA; subarachnoid hemorrhage; biomarkers; early brain injury; delayed cerebral ischemia; neurovascular; NanoString
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Funding
- Spanish Ministry of Economy and Competitiveness (Instituto de Salud Carlos III) [PI19/00936]
- European Regional Development Fund [ERDF])
- Fundacio la Marato de TV3 [17/C/2017]
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This study found that there was overexpression of miRNAs in the acute stage of subarachnoid hemorrhage in comparison with non-SAH controls. Specific miRNAs were also found to be differentially expressed based on clinical severity and the development of delayed cerebral ischemia and midterm functional outcomes. These observations suggest the potential utility of miRNAs as prognostic and diagnostic biomarkers in SAH patients.
IntroductionDelayed cerebral ischemia (DCI) is a dreadful complication present in up to 30% of patients with spontaneous subarachnoid hemorrhage (SAH). Indeed, DCI is one of the main causes of long-term disability in SAH, yet its prediction and prevention are troublesome in poor-grade SAH cases. In this prospective study, we explored the potential role of micro ribonucleic acid (microRNA, abbreviated miRNAs)-small non-coding RNAs involved in clue gene regulation at the post-transcriptional level-as biomarkers of neurological outcomes in SAH patients. MethodsWe analyzed the expression of several miRNAs present in the cerebrospinal fluid (CSF) of SAH patients during the early stage of the disease (third-day post-hemorrhage). NanoString Technologies were used for the characterization of the CSF samples. ResultsWe found an overexpression of miRNAs in the acute stage of 57 SAH in comparison with 10 non-SAH controls. Moreover, a differential expression of specific miRNAs was detected according to the severity of clinical onset, but also regarding the development of DCI and the midterm functional outcomes. ConclusionThese observations reinforce the potential utility of miRNAs as prognostic and diagnostic biomarkers in SAH patients. In addition, the identification of specific miRNAs related to SAH evolution might provide insights into their regulatory functions of pathophysiological pathways, such as the TGF-beta inflammatory pathway and blood-brain barrier disruption.
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