Extending the clinical capabilities of short- and long-lived positron-emitting radionuclides through high sensitivity PET/CT

This review describes the main benefits of using long axial field of view (LAFOV) PET in clinical applications. As LAFOV PET is the latest development in PET instrumentation, many studies are ongoing that explore the potentials of these systems, which are characterized by ultra-high sensitivity. This review not only provides an overview of the published clinical applications using LAFOV PET so far, but also provides insight in clinical applications that are currently under investigation. Apart from the straightforward reduction in acquisition times or administered amount of radiotracer, LAFOV PET also allows for other clinical applications that to date were mostly limited to research, e.g., dual tracer imaging, whole body dynamic PET imaging, omission of CT in serial PET acquisition for repeat imaging, and studying molecular interactions between organ systems. It is expected that this generation of PET systems will significantly advance the field of nuclear medicine and molecular imaging.

Automated summary

This review discusses the benefits of using long axial field of view (LAFOV) PET in clinical applications. LAFOV PET systems have ultra-high sensitivity and offer various clinical applications, including dual tracer imaging and whole body dynamic PET imaging. It is expected that this generation of PET systems will significantly advance the field of nuclear medicine and molecular imaging.