Journal
VIRUSES-BASEL
Volume 14, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/v14112490
Keywords
hepatitis B virus; hepatitis C virus; chronic infection; liver; liver biopsy
Categories
Funding
- Swiss National Science Foundation
- [310030B_147089]
- [310030_166202]
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Infectious diseases cause significant human suffering and socioeconomic burden worldwide. Understanding the interactions between human pathogens and hosts is crucial for developing effective treatment strategies. However, there is a lack of model systems that accurately replicate these interactions. The tropism of hepatitis B (HBV) and C (HCV) viruses for the human liver poses challenges in studying their interactions during the natural progression of these infections. This review summarizes the efforts to advance our knowledge of virus-host interactions in chronic HCV and HBV infection through the analysis of surplus liver biopsy tissue donated by patients.
Infectious diseases are a major contributor to human suffering and the associated socioeconomic burden worldwide. A better understanding of human pathogen-host interactions is a prerequisite for the development of treatment strategies aimed at combatting human pathogen-induced diseases. Model systems that faithfully recapitulate the pathogen-host interactions in humans are critical to gain meaningful insight. Unfortunately, such model systems are not yet available for a number of pathogens. The strict tropism of the hepatitis B (HBV) and C (HCV) viruses for the human liver has made it difficult to study their virus-host interactions during the natural history of these infections. In this case, surplus liver biopsy tissue donated by patients provides an opportunity to obtain a snapshot of the phenomenological and molecular aspects of the human liver of chronically HCV or HBV-infected patients. In this review, we will briefly summarize our own efforts over the years to advance our knowledge of the virus-host interactions during the natural history of chronic HCV and HBV infection.
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