4.6 Article

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

Related references

Note: Only part of the references are listed.
Article Microbiology

Elucidating the Antiviral Mechanism of Different MARCH Factors

Supawadee Umthong et al.

Summary: This study explores the antiviral mechanism of MARCH proteins, which act as antiretroviral factors by reducing the incorporation of envelope glycoproteins in budding virions. A comprehensive analysis reveals that MARCH proteins have broad antiviral functions, restricting envelope glycoproteins from various viruses to different degrees. Comparisons between human and mouse MARCH genes show differences in the mechanism of restriction among MARCH proteins.
Article Microbiology

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins

Cheng Man Lun et al.

Summary: The newly discovered cellular inhibitory protein MARCH8 has been found to antagonize a variety of viral glycoproteins, including those from HIV-1, Ebola virus, and SARS-CoV-2. Through its E3 ubiquitin ligase activity, MARCH8 targets viral glycoproteins, reducing their infectivity in virions.
Article Microbiology

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells

Fernando Villalon-Letelier et al.

Summary: MARCH8 restricts influenza A virus at a late stage in replication by reducing incorporation of envelope glycoproteins into virions, demonstrating a unique mechanism of antiviral activity. The N-terminal cytoplasmic domain of MARCH8 is essential for this anti-IAV activity, distinguishing it from MARCH1.
Article Multidisciplinary Sciences

MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes

Xiaoman Liu et al.

Summary: MARCH8 acts as an important player in the host anti-influenza virus defense by targeting M2 protein and inhibiting viral replication. The discovery that H1N1 influenza A virus has evolved to resist MARCH8-mediated ubiquitination and degradation sheds light on the inhibitory effects of MARCH8 on virus transmission within the human population.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation

Jian Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Immunology

MARCH ligases in immunity

Haiyin Liu et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Membrane-associated RING-CH (MARCH) 1 and 2 are MARCH family members that inhibit HIV-1 infection

Yanzhao Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemical Research Methods

Overview of the membrane-associated RING-CH (MARCH) E3 ligase family

Johannes Bauer et al.

NEW BIOTECHNOLOGY (2017)

Article Multidisciplinary Sciences

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels

Arvindhan Nagarajan et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins

Takuya Tada et al.

NATURE MEDICINE (2015)

Article Multidisciplinary Sciences

Cell Adhesion in Zebrafish Embryos Is Modulated by March8

Mi Ha Kim et al.

PLOS ONE (2014)

Article Immunology

Autoregulation of MARCH1 Expression by Dimerization and Autoubiquitination

Marie-Claude Bourgeois-Daigneault et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation

Rui Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Immunology

Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints

Masayasu Toyomoto et al.

INTERNATIONAL IMMUNOLOGY (2011)

Article Biochemistry & Molecular Biology

Ubiquitin-mediated Regulation of CD86 Protein Expression by the Ubiquitin Ligase Membrane-associated RING-CH-1 (MARCH1)

Kathleen Corcoran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cell Biology

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

Craig A. Eyster et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Review Biochemistry & Molecular Biology

The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function

Nobuhiro Nakamura

MEMBRANES (2011)