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Hyposplenism, an underrecognised immune diffeciency: Is sonography helpful?

Journal

ZEITSCHRIFT FUR GASTROENTEROLOGIE
Volume 61, Issue 7, Pages 852-861

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/a-1901-9569

Keywords

hyposplenism; asplenia; ultrasound; spleen; Howell-Jolly bodies

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The immunodeficiency syndrome of functional hyposplenia/asplenia is often overlooked, but technetium-99m scintigraphy and ultrasound can aid in diagnosing this disease.
The immunodeficiency syndrome of functional hyposplenia/asplenia is frequently unrecognized. The gold standard procedure for the diagnosis of this disease is technetium-99m scintigraphy of heat-denatured erythrocytes and the detection of pitted erythrocytes or Howell-Jolly bodies. Initial work suggests that this clinical presentation is associated with a small spleen. The aim of this review is to describe the value of B-mode and contrast-enhanced ultrasound in the identification of immunodeficiency caused by functional hyposplenism.

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