Comprehensive profiling of the distribution, risks and priority of pharmaceuticals and personal care products: A large-scale study from rivers to coastal seas

Pharmaceuticals and personal care products (PPCPs) have captured global concern due to their detrimental effects on aquatic organisms. Thirty PPCPs were analyzed in the water of the Jiaozhou Bay watershed, the Yellow Sea (YS) and the East China Sea (ECS) in China to investigate the distribution and risk of PPCPs from rivers to coastal seas, which are not yet well documented. The results showed the prevalence of the target PPCPs with a downward trend in detection frequencies and total concentrations from rivers (675 ng/L on average) to bay (166 ng/L) and to coastal seas (103 ng/L). Antibiotics and personal care products (PCPs) were dominated by amoxicillin (AMOX) and p-hydroxybenzoic acid, respectively, while the dominant estrogens were inconsistent in different regions. Spatially, the total PPCP concentrations were higher in the ECS than that in the YS due to the larger quantity of sewage flowing into the ECS. Additionally, higher total PPCP concentrations were appeared in the southeastern waters outside the Yangtze estuary and Hangzhou Bay of the ECS. The PPCP mixtures might pose medium to high risk to aquatic organisms in general. The total risk quotient (RQT) of antibiotics and PCPs to algae was higher than that to crustacean and fish, while estrogens may cause the greatest damage to fish. Despite the higher PPCP concentrations in river water than in seawater, the RQT of PPCPs in bay water was generally higher than that in river water, which may be associated with the susceptibility of marine organisms. Furthermore, the high-risk pollutants that need special concern in different regions were clarified, showing that AMOX, 17ss-estradiol, and estriol deserve the highest-priority in rivers, bay, and coastal waters, respectively.

Automated summary

Pharmaceuticals and personal care products (PPCPs) have been a global concern for their harmful effects on aquatic organisms. A study in China analyzed the occurrence and risk of PPCPs in the Jiaozhou Bay watershed, the Yellow Sea, and the East China Sea. The results showed a decrease in detection frequencies and total concentrations of PPCPs from rivers to coastal seas. PPCP mixtures pose medium to high risk to aquatic organisms, with antibiotics and personal care products posing a higher risk to algae and estrogens posing the greatest risk to fish.