4.3 Review

Advances in myelodysplastic/myeloproliferative neoplasms

Related references

Note: Only part of the references are listed.
Article Hematology

Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management

Mrinal M. Patnaik et al.

Summary: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Diagnosis is based on the presence of peripheral blood monocytosis and bone marrow dysplasia. Mutations and risk factors affect prognosis, and hypomethylating agents are commonly used for treatment. Allogeneic stem cell transplant is a potential curative option.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

Article Pathology

Myelodysplastic/myeloproliferative neoplasms-unclassifiable with isolated isochromosome 17q represents a distinct clinico-biologic subset: a multi-institutional collaborative study from the Bone Marrow Pathology Group

Rashmi Kanagal-Shamanna et al.

Summary: The study revealed that patients with MDS/MPN-i(17q) were typically younger with lower platelet and neutrophil counts, commonly displayed bilobed neutrophils and had a higher mutation frequency. These patients had a poorer prognosis and shorter overall survival compared to those without i(17q).

MODERN PATHOLOGY (2022)

Article Hematology

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Daniel A. Arber et al.

Summary: In 2016, the WHO, Society for Hematopathology, and European Association for Haematopathology collaborated to update the classification of myeloid neoplasms and acute leukemias, advancing the field of myeloid neoplasms and acute leukemias.

BLOOD (2022)

Review Oncology

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Joseph D. Khoury et al.

Summary: This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms, emphasizing the refinement of diagnostic criteria and the importance of actionable biomarkers, while maintaining global applicability.

LEUKEMIA (2022)

Article Hematology

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - 2021 update on diagnosis, risk-stratification, and management

Mrinal M. Patnaik et al.

Summary: Ring sideroblasts (RS) are erythroid precursors with abnormal perinuclear mitochondrial iron accumulation, associated with myeloid neoplasms MDS-RS and MDS/MPN-RS-T; SF3B1 mutations are common in these diseases; treatment options include luspatercept for anemia and consideration of aspirin therapy in MDS/MPN-RS-T.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Pathology

IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias

Samuel G. Katz et al.

Summary: The study identified IRF8 as a potential biomarker candidate for diagnosing and tracking Acute Monocytic Leukemias (AMoL) on bone marrow core biopsies by examining specific gene expression profiles of monocyte progenitors. Positive staining for IRF8 showed high correlation with blast count in AMoL and chronic myelomonocytic leukemia cases, while having low correlation in other acute myeloid leukemia subtypes and normal control cases. The sensitivity, specificity, positive predictive value, and negative predictive value of using IRF8 as an immunostain for categorizing cases as AMoL were demonstrated to be 98%, 82%, 86%, and 98% respectively, indicating its potential clinical utility.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

Article Hematology

Relationship between clone metrics and clinical outcome in clonal cytopenia

Anna Galli et al.

Summary: Study on clonal cytopenia of undetermined significance (CCUS) revealed varying mutation patterns and clone metrics parameters, indicating diverse clinical expressions. Unsupervised clustering analysis based on mutation profiles identified two major clusters with different overall survival and progression risks. Clone metrics play a critical role in informing clinical decision-making for patients with clonal cytopenia.

BLOOD (2021)

Review Hematology

Incorporating flow cytometry and next-generation sequencing in the diagnosis of CMML. Are we ready for prime?

Eric Solary et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2020)

Review Hematology

How I investigate chronic myelomonocytic leukemia

Valentina Fabiola Ilenia Sangiorgio et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2020)

Article Hematology

Concordance among hematopathologists in classifying blasts plus promonocytes: A bone marrow pathology group study

Kathryn Foucar et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2020)

Letter Hematology

Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance

Rangit Vallapureddy et al.

AMERICAN JOURNAL OF HEMATOLOGY (2017)

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Turning the tide in myelodysplastic/myeloproliferative neoplasms

Michael W. N. Deininger et al.

NATURE REVIEWS CANCER (2017)

Letter Hematology

Clinicopathologic and Molecular Characterization of Myeloid Neoplasms Harboring Isochromosome 17(q10)

Valeria Visconte et al.

AMERICAN JOURNAL OF HEMATOLOGY (2014)

Review Hematology

Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review

Mrinal M. Patnaik et al.

BRITISH JOURNAL OF HAEMATOLOGY (2014)

Article Oncology

Prognostic Score Including Gene Mutations in Chronic Myelomonocytic Leukemia

Raphael Itzykson et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Article Genetics & Heredity

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia

Rocco Piazza et al.

NATURE GENETICS (2013)