Journal
TRENDS IN PARASITOLOGY
Volume 39, Issue 3, Pages 158-159Publisher
CELL PRESS
DOI: 10.1016/j.pt.2022.12.011
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Eappen et al. present a method for in vitro production of a large quantity of sporozoites, addressing the challenge of mass production of infectious sporozoites from infected mosquitoes. This opens up new avenues for investigating sporozoite biology and scaling up sporozoite production for vaccine development.
The whole-sporozoite-based vaccine approach has been limited by the difficulty of mass production of infectious sporozoites from infected mosquitoes. Eappen et al. describe a method for producing a large quantity of sporozoites in vitro, which opens new areas of investigations in sporozoite biology and large-scale sporozoite production for vaccine development.
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