Analyzing the unperturbed HIV-1 T cell reservoir

The latent reservoir for HIV-1 prevents cure but is difficult to characterize due to the low frequency of latently infected cells and the absence of unique markers. Sun et al. used single cell analysis of T cell surface phenotypes to provide evidence for immune selection of reservoir cells.

Automated summary

The latent reservoir for HIV-1, which hinders a cure, is challenging to study due to the scarcity of latently infected cells and the absence of distinctive markers. Sun et al. used single cell analysis of T cell surface phenotypes to demonstrate the immune selection of reservoir cells.