Journal
TRENDS IN GENETICS
Volume 39, Issue 4, Pages 320-333Publisher
CELL PRESS
DOI: 10.1016/j.tig.2022.12.004
Keywords
-
Categories
Ask authors/readers for more resources
Studies using highly sensitive targeted RNA enrichment methods have shown that there is still a large portion of the human transcriptome to be discovered, and that most of the genome is transcribed in a complex, interleaved fashion. These findings are consistent with single-cell transcriptome profiling endeavors that reveal the existence of multiple novel, cell type-specific transcripts. The review discusses the current status of targeted RNA enrichment techniques, their application to the discovery of novel cell type-specific transcripts, and their impact on our understanding of the human genome and transcriptome.
Studies using highly sensitive targeted RNA enrichment methods have shown that a large portion of the human transcriptome remains to be discovered and that most of the genome is transcribed in a complex, interleaved fashion charac-terized by a complex web of transcripts emanating from protein coding and non-coding loci. These results resonate with those from single-cell transcriptome profiling endeavors that reveal the existence of multiple novel, cell type-specific transcripts and clearly demonstrate that our understanding of the complexities of the human transcriptome is far from being complete. Here, we review the cur-rent status of the targeted RNA enrichment techniques, their application to the discovery of novel cell type-specific transcripts, and their impact on our under-standing of the human genome and transcriptome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available