SLiM-binding pockets: an attractive target for broad-spectrum antivirals

Short linear motif (SLiM)-mediated interactions offer a unique strategy for viral intervention due to their compact interfaces, ease of convergent evolution, and key functional roles. Consequently, many viruses extensively mimic host SLiMs to hijack or deregulate cellular pathways and the same motif-binding pocket is often targeted by numerous unrelated viruses. A toolkit of therapeutics targeting commonly mimicked SLiMs could provide prophylactic and therapeutic broadspectrum antivirals and vastly improve our ability to treat ongoing and future viral outbreaks. In this opinion article, we discuss the therapeutic relevance of SLiMs, advocating their suitability as targets for broad-spectrum antiviral inhibitors.

Automated summary

SLiM-mediated interactions provide an unique strategy for viral intervention by mimicry of host SLiMs. Targeting commonly mimicked SLiMs could broaden the spectrum of antiviral drugs and improve our ability to handle viral outbreaks. In this opinion article, we advocate the therapeutic relevance of SLiMs as targets for broad-spectrum antiviral inhibitors.