4.5 Article

Cyclotron vs generator-produced 68Ga PSMA: a single-institution, prospective clinical trial

Related references

Note: Only part of the references are listed.
Article Oncology

68Ga-PSMA-HBED-CC PET/MRI is superior to multiparametric magnetic resonance imaging in men with biochemical recurrent prostate cancer: A prospective single-institutional study

Juana Martinez et al.

Summary: PSMA PET/MRI demonstrates a higher detection rate than conventional mpMRI in patients with biochemically recurrent prostate cancer, with consistent results across PSA levels, treatment modalities, and androgen deprivation therapy time. The study findings suggest that PSMA PET/MRI has superior sensitivity compared to mpMRI.

TRANSLATIONAL ONCOLOGY (2022)

Article Biochemical Research Methods

Synthesis of 68Ga-radiopharmaceuticals using both generator-derived and cyclotron-produced 68Ga as exemplified by [68Ga]Ga-PSMA-11 for prostate cancer PET imaging

Melissa E. Rodnick et al.

Summary: [Ga-68]Ga-PSMA-11, a radiopharmaceutical approved for prostate cancer PET imaging, is in high demand. This study presents synthesis methods for [Ga-68]Ga-PSMA-11 using generator-eluted and cyclotron-produced Ga-68. Both methods are suitable for clinical production, but the cyclotron method is more promising for meeting high patient volumes in the long term.

NATURE PROTOCOLS (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

PSMA PET/CT vs. CT alone in newly diagnosed biochemical recurrence of prostate cancer after radical prostatectomy: Comparison of detection rates and therapeutic implications

J. Morawitz et al.

Summary: PSMA PET/CT is superior to CT alone in detecting biochemical recurrence in PCa patients after radical prostatectomy and offered additional therapeutic options in a substantial number of patients.

EUROPEAN JOURNAL OF RADIOLOGY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Somatostatin Receptor Imaging and Theranostics: Current Practice and Future Prospects

Sonya Park et al.

Summary: This comprehensive review discusses the new era of precision diagnostics and therapy for neuro-endocrine neoplasms, highlighting the role of SSTR PET in various aspects and challenges. The researchers provide a standardized reporting template for SSTR PET, offering guidance for future research and clinical practice.

JOURNAL OF NUCLEAR MEDICINE (2021)

Review Medicine, General & Internal

Radiation Therapy Planning of Thoracic Tumors: A Review of Challenges Associated With Lung Toxicities and Potential Perspectives of Gallium-68 Lung PET/CT Imaging

Francois Lucia et al.

Summary: Despite the introduction of new radiotherapy techniques, radiation induced lung injury remains a significant adverse event of thoracic radiation therapy. Functional lung avoidance radiation therapy aims to better preserve lung function and reduce pulmonary toxicity. The recent advent of (68)Gallium V/Q lung PET/CT imaging offers potential for more accurate lung functional mapping and personalized lung radiation therapy plans.

FRONTIERS IN MEDICINE (2021)

Article Chemistry, Medicinal

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE

Helge Thisgaard et al.

Summary: In response to the increasing clinical demand for gallium-68, a high-yield, automated method has been developed for producing multi-Curie levels of [Ga-68]GaCl3 from solid zinc-68 targets. This method led to record-high purified gallium-68 activities and successful labelling of PSMA-11 and DOTATATE, showing promising results for clinical use in terms of quality control.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Management Impact of 68Ga-DOTATATE PET/CT in Neuroendocrine Tumors

Redmond-Craig Anderson et al.

Summary: This retrospective study aimed to investigate the diagnostic value and clinical impact of Ga-68-DOTATATE PET/CT in the therapeutic management of patients with neuroendocrine tumors. Results showed that Ga-68-DOTATATE PET/CT improved lesion detection in 33.3% of patients and impacted therapeutic management in 23.8% of patients.

NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Taking cyclotron 68Ga production to the next level: Expeditious solid target production of 68Ga for preparation of radiotracers

Bryce J. B. Nelson et al.

NUCLEAR MEDICINE AND BIOLOGY (2020)

Article Chemistry, Medicinal

Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid target

Melissa E. Rodnick et al.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2020)

Review Chemistry, Medicinal

[Ga-68]Ga-DOTA-TOC: The First FDA-Approved Ga-68-Radiopharmaceutical for PET Imaging

Ute Hennrich et al.

PHARMACEUTICALS (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Rapid and automated production of [68Ga]gallium chloride and [68Ga] Ga-DOTA-TATE on a medical cyclotron

William Tieu et al.

NUCLEAR MEDICINE AND BIOLOGY (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE): Proposed miTNM Classification for the Interpretation of PSMA-Ligand PET/CT

Matthias Eiber et al.

JOURNAL OF NUCLEAR MEDICINE (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Repeatability of [68Ga]DKFZ11-PSMA PET Scans for Detecting Prostate-specific Membrane Antigen-positive Prostate Cancer

Joseph R. Osborne et al.

MOLECULAR IMAGING AND BIOLOGY (2017)

Article Computer Science, Interdisciplinary Applications

Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support

Paul A. Harris et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2009)