☆ 4.5 Article

circ-ZEB1 regulates epithelial-mesenchymal transition and chemotherapy resistance of colorectal cancer through acting on miR-200c-5p

TRANSLATIONAL ONCOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Oncology

hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway

Wei Zhang et al.

Summary: This study found that hsa_circ_0000231 was upregulated in colorectal cancer (CRC) and associated with poor prognosis. Inhibition of hsa_circ_0000231 suppressed CRC cell proliferation and tumorigenesis. Mechanistically, hsa_circ_0000231 might act as a competing endogenous RNA of miR-375 to promote CCND2 and interact with IGF2BP3 protein to prevent CCND2 degradation.

CANCER CELL INTERNATIONAL (2022)

Add to Collection

Article Oncology

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma

Jia Li et al.

Summary: This study reveals that circRPN2 can suppress the metastasis of hepatocellular carcinoma by accelerating the degradation of ENO1 and regulating the miR-183-5p/FOXO1 axis to inhibit glycolysis and tumor progression. Additionally, the expression level of circRPN2 can serve as a novel indicator for HCC prognosis.

CANCER RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p

Yu-Zhong Yu et al.

Summary: Hsa_circ_0003258 is upregulated in prostate cancer and associated with tumor progression. It promotes cell migration and tumor metastasis, while knockdown of hsa_circ_0003258 has the opposite effect. Mechanistically, hsa_circ_0003258 functions by sponging miR-653-5p and increasing the expression of ARHGAP5. Additionally, hsa_circ_0003258 physically binds to IGF2BP3 and enhances HDAC4 mRNA stability, activating the ERK signaling pathway and triggering EMT programming.

MOLECULAR CANCER (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance

Zhipeng Jiang et al.

Summary: The overexpression of circPTK2 is associated with liver metastasis, clinical stage, and chemoresistance in colorectal cancer (CRC). Silencing circPTK2 inhibits the progression and chemoresistance of CRC by regulating the miR-136-5p and YTHDF1 signaling pathway.

BIOENGINEERED (2022)

Add to Collection

Review Medicine, Research & Experimental

Non-coding RNAs regulating epithelial-mesenchymal transition: Research progress in liver disease

Xiang Yang et al.

Summary: This review focuses on the regulatory role of non-coding RNA (ncRNA) in epithelial-mesenchymal transformation (EMT) in liver diseases. Studies have found that ncRNA regulation of EMT plays a significant role in the pathological progression and diagnosis and treatment of liver diseases.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma

Weiwei Liu et al.

Summary: High expression of circ-ZEB1 and PIK3CA is associated with poor prognosis in HCC. Circ-ZEB1 promotes the expression of PIK3CA by silencing miR-199a-3p, affecting HCC proliferation and apoptosis.

MOLECULAR CANCER (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Circular RNA PLCE1 promotes epithelial mesenchymal transformation, glycolysis in colorectal cancer and M2 polarization of tumor-associated macrophages

Bo Yi et al.

Summary: This study aimed to investigate the biological functions of circPLCE1 on epithelial mesenchymal transformation (EMT), glycolysis, and tumor-associated macrophage (TAM) polarization in colorectal cancer (CRC). The results showed that circPLCE1 expression was increased, while miR-485-5p expression was decreased in CRC. Knockdown of circPLCE1 inhibited CRC proliferation, glycolysis, and M2 macrophage polarization, while decreased miR-485-5p accelerated EMT, glycolysis, and TAM M2 polarization in CRC. Mechanism studies revealed that circPLCE1 acted as a competitive endogenous RNA to mediate ACTG1 expression through binding with miR-485-5p. In summary, circPLCE1 promotes EMT, glycolysis, and TAM M2 polarization through regulating the miR-485-5p/ACTG1 axis in CRC.

BIOENGINEERED (2022)

Add to Collection

Article Oncology

RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers

Pei-Qiu Cheng et al.

Summary: This study found that circRNA may be associated with the occurrence of 5-Fu resistance and constructed a regulatory network of circRNA-miRNA-mRNA.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022)

Add to Collection

Review Oncology

Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance

Xiaolin Wang et al.

Summary: Gastric cancer is an aggressive malignancy with a high mortality rate primarily caused by metastatic lesions. Recent studies have shown that covalently closed circular RNAs (circRNAs) play crucial roles in gastric cancer, exhibiting dysregulated patterns in invasion and metastasis. However, the specific functions of circRNAs in metastatic gastric cancer remain unclear. This review outlines the functional circRNAs related to metastatic gastric cancer and drug resistance, providing insights into their underlying mechanisms and potential for future therapeutic interventions.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Review Oncology

Role of circular RNAs in the diagnosis, regulation of drug resistance and prognosis of lung cancer

Chengpeng Sang et al.

Summary: Lung cancer is a common malignant tumor in China, causing high mortality rates in both urban and rural areas. Many lung cancer patients lack early symptoms, leading to late-stage diagnosis and poor prognosis. Circular RNAs (circRNAs) show potential as biomarkers for early diagnosis and prognosis prediction of lung cancer, as well as novel targets for therapy design.

ONCOLOGY LETTERS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Review on circular RNAs and new insights into their roles in cancer

Xiaozhu Tang et al.

Summary: circRNAs are a class of interesting and conserved single-stranded RNA molecules that play important roles in various biological processes, especially in microRNA sponges, gene splicing and transcription regulation, RNA-binding protein sponges, and protein/peptide translation. They are involved in various human diseases, particularly cancers, and may serve as better predictive biomarkers and therapeutic targets for cancer treatment.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Cell Biology

CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer

Junwei Tang et al.

Summary: Colorectal cancer is a common type of cancer worldwide, with increasing incidence and mortality rates in China. The study found that elevated levels of circ-LNLM in tumor tissues of LNLM1 patients were associated with liver metastasis and vascular invasion, suggesting it could potentially serve as a diagnostic and prognostic biomarker for LNLM1 patients.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Cell Biology

Circular RNA hsa_circ_0006401 promotes proliferation and metastasis in colorectal carcinoma

Chenjing Zhang et al.

Summary: The study revealed that hsa_circ_0006401 is closely related to CRC metastasis and showed increased expression in metastatic CRC tissue samples. Silencing hsa_circ_0006401 expression inhibited proliferation and migration in vitro, while downregulation of hsa_circ_0006401 expression reduced CRC proliferation and liver metastasis in vivo. Hsa_circ_0006401 promotes CRC proliferation and migration by encoding peptides.

CELL DEATH & DISEASE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner

Xin Liu et al.

Summary: The study identified an intron-derived circRNA, circMYH9, significantly upregulated in colorectal cancer tissues. CircMYH9 promotes colorectal cancer proliferation through modulating serine/glycine metabolism and redox homeostasis in a p53-dependent manner.

MOLECULAR CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

Jiaqi Wang et al.

Summary: The study revealed that circSPARC is upregulated in CRC patients and is associated with tumor progression and survival rates. Silencing circSPARC can inhibit CRC cell migration and proliferation. CircSPARC interacts with miR-485-3p to upregulate JAK2 expression, leading to the accumulation of p-STAT3.

MOLECULAR CANCER (2021)

Add to Collection

Article Oncology

MiR-200c-3p Modulates Cisplatin Resistance in Biliary Tract Cancer by ZEB1-Independent Mechanisms

Florian Posch et al.

Summary: Biliary tract cancer is a rare malignancy with poor survival rates, and cisplatin-based treatments are commonly used as first-line strategies. MiR-200c-3p may play a significant role in cisplatin resistance in biliary tract cancer, independent of its interaction with ZEB1.

CANCERS (2021)

Add to Collection

Review Pharmacology & Pharmacy

5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future

Sona Vodenkova et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Add to Collection

Article Oncology

Colorectal cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

CircRNA_0005075 suppresses carcinogenesis via regulating miR-431/p53/epithelial-mesenchymal transition axis in gastric cancer

Jiaming Wu et al.

CELL BIOCHEMISTRY AND FUNCTION (2020)

Add to Collection

Article Oncology

Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer

Xinyi Wang et al.

MOLECULAR ONCOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

UTMD inhibit EMT of breast cancer through the ROS/miR-200c/ZEB1 axis

Dandan Shi et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Pathology

Roles of a TMPO-AS1/microRNA-200c/TMEFF2 ceRNA network in the malignant behaviors and 5-FU resistance of ovarian cancer cells

Haoshan Li et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2020)

Add to Collection

Article Oncology

ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas

Lucia Sommerova et al.

CANCERS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Circular RNA circ-ZEB1 acts as an oncogene in triple negative breast cancer via sponging miR-448

Xinhong Pei et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

Add to Collection

Article Oncology

Curcumin Modifies Epithelial-Mesenchymal Transition in Colorectal Cancer Through Regulation of miR-200c/EPM5

Hui Wang et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Add to Collection

Article Cell Biology

Circular RNA circ_ PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer

Hongping Wang et al.

AGING-US (2020)

Add to Collection

Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

Add to Collection

Review Cell Biology

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

被撤回的出版物: miR-200c, a tumor suppressor that modulate the expression of cancer stem cells markers and epithelial-mesenchymal transition in colorectal cancer (Retracted article. See vol. 123, pg. 1116, 2022)

Fateme Karimi Dermani et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Add to Collection

Article Oncology

Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7

Xiaomin Li et al.

JOURNAL OF PATHOLOGY (2018)

Add to Collection

Article Food Science & Technology

Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by Downregulating Bmi-1 Through Enhanced miR-200c Expression

Zhiyao Xu et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

Add to Collection

Article Oncology

Circ-ZEB1.33 promotes the proliferation of human HCC by sponging miR-200a-3p and upregulating CDK6

Yuhua Gong et al.

CANCER CELL INTERNATIONAL (2018)

Add to Collection

Review Oncology

EMT in cancer

Thomas Brabletz et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Article Oncology

Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer: a JSMO-ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS

T. Yoshino et al.

ANNALS OF ONCOLOGY (2018)

Add to Collection

Article Oncology

MicroRNA-200c regulates cisplatin resistance by targeting ZEB2 in human gastric cancer cells

Tao Jiang et al.

ONCOLOGY REPORTS (2017)

Add to Collection

Review Genetics & Heredity

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

Merve Mutlu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

Add to Collection

Review Genetics & Heredity

Endogenous microRNA sponges: evidence and controversy

Daniel W. Thomson et al.

NATURE REVIEWS GENETICS (2016)

Add to Collection

Review Cell Biology

The biogenesis and emerging roles of circular RNAs

Ling-Ling Chen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Add to Collection

© Peeref 2019-2024. All rights reserved.