Fecal Microbiota Transplantation Alleviated Cerebral Ischemia Reperfusion Injury in Obese Rats

Review Biochemistry & Molecular Biology

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

Anamaria Jurcau et al.

Summary: Stroke is the second leading cause of death worldwide, and neuroinflammation plays a significant role in this condition. Neuroinflammation leads to tissue injury and functional recovery, and therapeutic attempts targeting neuroinflammation have been made.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Gastroenterology & Hepatology

Effect of intestinal microbiota transplantation on cerebral ischemia reperfusion injury in aged mice via inhibition of IL-17

Yun Feng et al.

Summary: This study found that intestinal microbiota transplantation can alleviate cerebral ischemia reperfusion injury in aged mice by restoring their microbiota environment and inhibiting IL-17 in the gut, serum, and brain tissue.

NEUROGASTROENTEROLOGY AND MOTILITY (2022)

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Review Biochemistry & Molecular Biology

THE ROLE OF OXIDATIVE STRESS IN THE DEVELOPMENT OF OBESITY AND OBESITY-RELATED METABOLIC DISORDERS

Emina Colak et al.

Summary: Obesity is defined as excessive accumulation of fat and is associated with diseases such as hypertension and diabetes. Oxidative stress may play a key role in the development of obesity and related complications.

JOURNAL OF MEDICAL BIOCHEMISTRY (2021)

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Article Cell Biology

Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury

Donglin Du et al.

Summary: The study demonstrates that traumatic brain injury alters gut microbiota, while fecal microbiota transplantation can restore dysbiosis and alleviate neurological deficits possibly through the TMA-TMAO-MsrA signaling pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Biology

APEX1 protects against oxidative damage-induced cardiomyocyte apoptosis

Zhaohui Hu et al.

Summary: APEX1 plays a protective role against oxidative damage in cardiomyocytes, reducing apoptosis and reversing oxidative damage induced by H2O2 through downregulating caspase 3 and Bax expression levels.

BIOCELL (2021)

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Article Biology

miR-21-3p alleviates neuronal apoptosis during cerebral ischemia-reperfusion injury by targeting SMAD2

Fei Tian et al.

Summary: This study investigated the role and mechanism of miR-21-3p and Smad2 in cerebral ischemic reperfusion injured neural cells. The findings suggest that downregulation of miR-21-3p and upregulation of Smad2 lead to neural cell apoptosis, while miR-21-3p protects neural cells by targeting and inhibiting Smad2 expression. Overexpression of Smad2 eliminates the protective effect of miR-21-3p, providing insights into the molecular mechanisms of ischemic stroke therapy.

BIOCELL (2021)

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Review Biochemistry & Molecular Biology

Ischemic stroke, obesity, and the anti-inflammatory role of melatonin

Nuttapong Yawoot et al.

Summary: Obesity is a major risk factor for ischemic stroke and often coexists with it. The susceptibility for ischemic brain damage increases significantly with concomitant obesity, and inflammation plays a key role. Melatonin shows potential in exerting anti-inflammatory effects and providing protection against obesity and ischemic stroke, although more research is needed on its effectiveness in cases of ischemic stroke with obesity-induced inflammation.

BIOFACTORS (2021)

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Review Nutrition & Dietetics