Platelet dysfunction and thrombus instability in flow conditions in patients with severe COVID-19

Article Anesthesiology

An observational study of intermediate- or high-dose thromboprophylaxis for critically ill COVID-19 patients

Sandra Jonmarker et al.

Summary: The study did not confirm or refute a difference in 90-day mortality between intermediate- and high-dose thromboprophylaxis, possibly due to a small sample size.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2022)

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Article Cardiac & Cardiovascular Systems

Association of cardiometabolic microRNAs with COVID-19 severity and mortality

Clemens Gutmann et al.

Summary: Research shows that circulating miRNAs from different tissue origins play a crucial role in the severity and prognosis of COVID-19, with miR-133a and miR-122 potentially associated with the risk of mortality in patients.

CARDIOVASCULAR RESEARCH (2022)

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Letter Hematology

Prothrombotic disturbances of hemostasis of patients with severe COVID-19: A prospective longitudinal observational study

Michael Hardy et al.

THROMBOSIS RESEARCH (2021)

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Article Critical Care Medicine

Impact of High-Dose Prophylactic Anticoagulation in Critically Ill Patients With COVID-19 Pneumonia

Charles Tacquard et al.

Summary: High-dose prophylactic anticoagulation is associated with a reduced risk of thrombotic complications in critically ill patients with COVID-19 without increasing the risk of bleeding. Further randomized controlled trials comparing prophylaxis with higher doses of anticoagulants are needed to confirm these results.

CHEST (2021)

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Article Medicine, General & Internal

Arterial Thrombotic Events in Adult Inpatients With COVID-19

Morgane Fournier et al.

Summary: This study evaluated the clinical course and risk factors for arterial thrombotic events in adult inpatients with COVID-19. Results showed that 5.6% of COVID-19 patients experienced arterial thrombotic events, which were associated with atypical patterns and increased in-hospital mortality rate. A D-dimer level above 1250 ng/mL may identify patients at risk for arterial thrombotic events.

MAYO CLINIC PROCEEDINGS (2021)

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Letter Hematology

Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19

Younes Zaid et al.

BLOOD ADVANCES (2021)

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Article Cardiac & Cardiovascular Systems

Adverse Outcome in COVID-19 Is Associated With an Aggravating Hypo-Responsive Platelet Phenotype

Waltraud C. Schrottmaier et al.

Summary: Unfavorable outcome in COVID-19 is associated with a hypo-responsive platelet phenotype that worsens with disease progression and may impact platelet-mediated immunoregulation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5

Huriye Ercan et al.

Summary: Platelets in COVID-19 patients show significant changes in activation phenotype, processing of coagulation factor F13A1, and phospholipid-binding protein ANXA5 compared to healthy individuals. These alterations in platelets are strongly associated with fatal outcomes during COVID-19 infection.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Editorial Material Anesthesiology

Anticoagulation in COVID-19: not strong for too long?

Charles Tacquard et al.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2021)

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Review Critical Care Medicine

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

Timothy Arthur Chandos Snow et al.

Summary: For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required. Its benefits may also lie in reducing the need for mechanical ventilation.

INTENSIVE CARE MEDICINE (2021)

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Article Hematology

Bleeding risk in hospitalized patients with COVID-19 receiving intermediate- or therapeutic doses of thromboprophylaxis

Pablo Demelo-Rodriguez et al.

Summary: Among patients hospitalized with COVID-19 receiving intermediate- or therapeutic-intensity anticoagulation, a major bleeding event occurred in 5.7%. Use of therapeutic-intensity anticoagulation, critical illness, and elevated D-dimer or ferritin levels at admission were associated with increased risk for major bleeding.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

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Article Biochemistry & Molecular Biology

Effects of Hyperhomocysteinemia on the Platelet-Driven Contraction of Blood Clots

Rustem Litvinov et al.

Summary: Hyperhomocysteinemia (HHcy) is associated with enhanced blood clot contraction due to direct and indirect platelet activation. Higher levels of homocysteine can lead to impaired platelet function and larger, more obstructive clots.

METABOLITES (2021)

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Article Multidisciplinary Sciences

Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection

Miroslava Cuperlovic-Culf et al.

Summary: This study analyzed the potential factors contributing to delirium susceptibility in postoperative patients by examining metabolic profiles. Significant changes were found in metabolites such as amino acids, acylcarnitines, and polyamines, linking delirium-prone patients to factors associated with Alzheimer's disease. Computational analysis also suggested a possible interaction between SARS-CoV-2 spike protein and MAOB, indicating a need for further investigation into the neurological and platelet-based complications of SARS-CoV-2 infection.

SCIENTIFIC REPORTS (2021)

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Article Critical Care Medicine