Successful and Safe Real-Time TDM-Guided Treatment of Invasive Pulmonary and Cerebral Aspergillosis Using Low-Dose Isavuconazole in a Patient with Primary Biliary Cirrhosis: Grand Round/A Case Study

Article Microbiology

Safety and Effectiveness of Isavuconazole Treatment for Fungal Infections in Solid Organ Transplant Recipients (ISASOT Study)

Arnau Monforte et al.

Microbiology Spectrum (2022)

Article Pharmacology & Pharmacy

Population Pharmacokinetics and Pharmacodynamic Target Attainment of Isavuconazole against Aspergillus fumigatus and Aspergillus flavus in Adult Patients with Invasive Fungal Diseases: Should Therapeutic Drug Monitoring for Isavuconazole Be Considered as Mandatory as for the Other Mold-Active Azoles?

Pier Giorgio Cojutti et al.

Summary: The study aimed to analyze the pharmacokinetics and pharmacodynamics of isavuconazole in hospitalized patients, showing that the efficacy of isavuconazole at standard maintenance doses is sustained and safe, without the need for adjustment based on clinical variables, and not requiring therapeutic drug monitoring like voriconazole and posaconazole.

PHARMACEUTICS (2021)

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Article Infectious Diseases

Therapeutic Drug Monitoring of Isavuconazole: Serum Concentration Variability and Success Rates for Reaching Target in Comparison with Voriconazole

Malene Risum et al.

Summary: This study evaluated the therapeutic drug monitoring of Isavuconazole in the treatment of aspergillosis and mucormycosis. The majority of patients achieved Isavuconazole serum levels within the therapeutic range with lower coefficient of variation compared to patients receiving Voriconazole.

ANTIBIOTICS-BASEL (2021)

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Article Dermatology