4.7 Article

Spectroscopic ellipsometry-based aptasensor platform for bisphenol a detection

Journal

TALANTA
Volume 253, Issue -, Pages -

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ELSEVIER
DOI: 10.1016/j.talanta.2022.123885

Keywords

Aptasensor; Biosensors; Bisphenol a; Spectroscopic ellipsometry

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In this study, a spectroscopic ellipsometry platform using aptamers was proposed for the detection of the endocrine-disrupting chemical Bisphenol A (BPA). The platform showed sensitive and selective detection of BPA, with a detection limit of 215 pM and 36 pM for two different BPA-specific aptamers. The sensor also exhibited good specificity and analytical performance.
Endocrine-disrupting chemicals (EDC) are pollutants that alter the function of the endocrine system by inter-fering with hormone biosynthesis, metabolism, or action. In this study, a spectroscopic ellipsometry platform is proposed using aptamers for the sensitive and selective detection of an EDC, 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A, BPA). Two different BPA-specific aptamers (Anti-BPA1 and Anti-BPA2) were immobilized to sil-icon wafer chips by the layer-by-layer self-assembly, a detection limit of 215 pM and 36 pM was obtained using the ellipsometric method for Anti-BPA1 and Anti-BPA2, respectively. Sensor specificity was tested with 2,2-Bis(4-hydroxyphenyl)butane and a maximum RSD of 3.8% was obtained. It has been reported that both aptasensors based on spectroscopic ellipsometry exhibit adequate analytical performance.

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