Journal
SYNTHETIC COMMUNICATIONS
Volume 53, Issue 1, Pages 49-57Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2022.2149343
Keywords
Cyclization; 2; 3-dihydronaphtho[2; 3-b]furan; 3; 4-dihydro-2H-benzo[g]chromene; naphthofuran; PTSA
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An efficient and facile method utilizing PTSA catalyst has been developed for the synthesis of 2,3-dihydronaphtho[2,3-b]furan and 3,4-dihydro-2H-benzo[g]chromene. This methodology shows high yield cyclization reaction of ortho-oxalate-, ortho-keto-, and ortho-formyl arylacetylenols. It is also successfully applied to the large-scale synthesis of the naphthofuran skeleton.
An efficient and facile method for producing 2,3-dihydronaphtho[2,3-b]furan and 3,4-dihydro-2H-benzo[g]chromene has been developed. This methodology utilizes an inexpensive and simple PTSA catalyst for the cyclization reaction of ortho-oxalate-, ortho-keto-, and ortho-formyl arylacetylenols to produce the corresponding products in high yield. This procedure was also successfully applied to the large-scale synthesis of the naphthofuran skeleton, which can be found in various natural products and pharmaceuticals.
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