Journal
SYNTHESIS-STUTTGART
Volume 55, Issue 9, Pages 1427-1440Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1993-4132
Keywords
asymmetric synthesis; indane-1,3-dione; isatin-based ketimine; organocatalysis; spiro[oxindole-3,2'-pyrrolidine
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A mild and efficient organocatalyzed [3+2] cycloaddition reaction between isatin-derived ketimines and 2-ylideneindane-1,3-diones has been achieved. The resulting spiro[oxindole-3,2'-pyrrolidine] compounds, containing both spiro indane-1,3-dione motif and a trifluoromethyl group, were obtained in high yields with good diastereo- and enantioselectivities.
A mild and efficient organocatalyzed [3+2] cycloaddition of isatin-derived ketimines and 2-ylideneindane-1,3-diones has been realized. The resulting spiro[oxindole-3,2 '-pyrrolidine]s bearing both a spiro indane-1,3-dione motif and a trifluoromethyl group were obtained in high yields with good diastereo-and enantioselectivities.
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