4.5 Article

Using a surrogate with heterogeneous utility to test for a treatment effect

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Summary: In studies requiring long-term and/or costly follow-up, surrogate markers are often used to evaluate the treatment effect. However, existing statistical methods often fail to account for the potential variation in the utility or strength of surrogate markers based on patient characteristics. This paper proposes an approach to measure surrogate strength as a function of baseline covariate and examines potential heterogeneity in surrogate marker utility.

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