Journal
STATA JOURNAL
Volume 22, Issue 4, Pages 908-923Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1536867X221141012
Keywords
st0695; crtrest; ratio estimator; intervention effects; event rate; cluster randomized trial
Funding
- National Medical Research Council, Singapore
- [MOH-000526]
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The study describes five asymptotically unbiased estimators of intervention effects on event rates in nonmatched and matched-pair cluster randomized trials. It also presents a bias-corrected version of the estimators for use when the number of clusters is small. These estimators can be used to estimate the total effect and the direct effect.
We describe five asymptotically unbiased estimators of intervention effects on event rates in nonmatched and matched-pair cluster randomized trials, and we present a bias-corrected version of the estimators for use when the number of clusters is small. The estimators are the ratio of mean counts (r(1)), ratio of mean cluster-level event rates (r(2)), ratio of event rates (r(3)), double ratio of counts (r(4)), and double ratio of event rates (r(5)). r(1), r(2), and r(3) estimate the total effect, which comprises the direct and indirect effects; r(4) and r(5) estimate the direct effect. We describe a new command, crtrest, that provides these ratio estimators and their standard errors in nonmatched and matched-pair cluster randomized trials.
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